IRF4

IRF4

A gene on chromosome 6p25-p23 that encodes a member of the interferon regulatory transcription factor (IRF) family, which is characterised by an unique tryptophan pentad-repeat DNA-binding domain. IRF4 is lymphocyte specific and negatively regulates Toll-like-receptor (TLR)-signalling, which is central to activating the innate and adaptive immune systems.

Molecular pathology
A chromosomal translocation involving IRF4 and the IgH locus, t(6;14)(p25;q32), has been linked to myeloma.
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analyzed 9 PCNSLs and identified recurrent somatic mutations in 37 genes involved in key biological processes, including transcription ( ETV6, IRF2BP2, EBF1, IRF4, and TBL1XR1 ), cell cycle ( PIM1, BTG1 ), nucleosome assembly ( HIST1H1D, HIST1H2AC ), and cell adhesion ( MUC16, ACTG1 ), as well as NF-?
This other enzyme, called IRF4, is a transcription factor that regulates the expression of a number of genes and proved key for controlling whether Tr1 cells developed.
Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas.
Additionally, genes regulated by activation of the SYK kinase and IRF4 transcription factor are significantly enriched in SLE naive and memory T cells, suggesting they are key drivers of T cell activation in SLE and a core part of the transcriptional regulatory circuitry driving the disease.
2) The IRF4 gene is involved in regulating production and storage of melanin.
According to researchers the gene identified, IRF4, is known to play a role in hair colour but this is the first time it has been associated with the greying of hair,Health News reported.
En la LMB tambien se han estudiado estos SNPs, encontrando frecuencias similares a las documentadas previamente en LLC, que ademas comprometen genes involucrados en el desarrollo de la enfermedad; por ejemplo rs757978, rs872071 y rs13397985 mapean a genes como FARP2, IRF4, y SP140, respectivamente (8).
The adrenaline signaling pathway and transcriptional signaling by FoxOl and IRF4 have been reported to activate ATGL and HSL (Eguchi et al.
The research findings described in this media release can be found in the 5 December online issue of Leukemia, under the title, "Fas Apoptosis Inhibitory Molecule (FAIM) is up-regulated by IGF-1 signaling and modulates Akt activation and IRF4 expression in Multiple Myeloma" by Jianxin Huo1, Shengli Xu1,2, Baohong Lin3, Wee-Joo Chng3,4,5, and Kong-Peng Lam1,2,6,7,8
Researchers have found that cells from a blood-borne cancer called multiple myeloma rely on the activity of a single protein, called IRF4, for the activation of a wide range of genes responsible for cell survival and spread.