IRF-8 is one of the unique IRFs that is only expressed in immune cells .
Apart from IRF1, IRF-3, IRF-7, and IRF-8, some studies have also briefly explored the role of IRF-5 and IRF-9 in malaria infection.
Interestingly, E2-2 can activate pDC-specific regulators, such as Spi-B, IRF-7, and IRF-8, as well as Bcl11a.
This study also showed that Batf could interact directly with IRF-4 and IRF-8. Thus, it appears that Batf3 is important in the terminal stages of [CD8.sup.+] cDC development and plays a role in maintaining this subset.
IRF-1, IRF-2, IRF-4, IRF-7, and IRF-8 have been implicated in DC development across many subsets.
IRF-8. In addition to Batf3, Id2, and E4BP4, [CD8.sup.+] cDCs also require IRF-8 (ICSBP; interferon consensus-binding protein) for their development [124, 125].
Experts at Hospital for Special Surgery say that their findings about the gene, called interferon regulator factor-8 (IRF-8), may lead to new treatments in future.
The researchers discovered that downregulation of IRF-8 (meaning that the gene produces less IRF-8 protein) increases the production of cells called osteoclasts that are responsible for breaking down bone.
The genome-wide study showed that the expression of IRF-8 was reduced by 75 percent in the initial phases of osteoclast development.
The genetically engineered mice deficient in IRF-8 had decreased bone mass and severe osteoporosis.
IRF-8. IRF-8, also known as interferon consensus sequence-binding protein (ICSBP), is a 393-amino acid-long "hematopoietic" IRF .
Bhattacharya, "IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors," Blood, vol.