IRF5

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IRF5

A gene on chromosome 7q32 that encodes a member of the interferon regulatory transcription factor (IRF) family, which have diverse roles such virus-mediated activation of interferons and modulation of cell growth, differentiation, apoptosis and immune system activity.
References in periodicals archive ?
We've previously found that a protein called interferon regulatory factor-5 (IRF-5) seems to push macrophages to change from a more 'peaceful', M2-type to the more aggressive M1-type', said Professor Irina Udalova at the Kennedy Institute of Rheumatology at Oxford University, 'so we wondered if 'deleting' IRF-5 might have a beneficial effect'.
To test this idea, the two research teams fed the mice that were lacking the gene coding for IRF-5 with a healthy diet or a high-fat one.
The mice without IRF-5 still got fat, but what was different was where they deposited this fat.
Despite being fatter, the mice without IRF-5 did better than the standard mice on this glucose challenge test.
Researchers at INSERM also found that IRF-5 levels were elevated in fatty tissue from very obese people, especially in their visceral fat.