IRF1

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IRF1

A gene on chromosome 5q31.1 that encodes interferon regulatory factor 1, a protein of the interferon regulatory transcription factor (IRF) family, which activates interferon (IFN) alpha and beta transcription, and acts as a transcription activator of genes induced by IFNs alpha, beta and gamma. IRF1 also plays a role in regulating apoptosis and tumour-suppression.
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References in periodicals archive ?
Kimura et al., "Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-[beta] gene regulatory elements," Cell, vol.
Taniguchi, "Induction of endogenous IFN-a and IFN-[beta] genes by a regulatory transcription factor, IRF-1," Nature, vol.
Hiscott, "A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity," Molecular and Cellular Biochemistry, vol.
Yokosawa, "PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1," FEBS Letters, vol.
Vogel, "Transcriptional regulation of lipopolysaccharide (LPS)-induced Toll-like receptor (TLR) expression in murine macrophages: role of interferon regulatory factors 1 (IRF-1) and 2 (IRF-2)," Journal of Endotoxin Research, vol.
Matsuyama et al., "Requirement for transcription factor IRF-1 in NO synthase induction in macrophages," Science, vol.
Ogasawara et al., "Multistage regulation of Th1-type immune responses by the transcription factor IRF-1," Immunity, vol.
Kock et al., "IFN-[gamma] represses IL-4 expression via IRF-1 and IRF-2," Immunity, vol.