ERN1

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ERN1

A gene on chromosome 17q24.2 that encodes the ubiquitously expressed endoplasmic reticulum (ER)-to-nucleus signalling 1 protein, which has intrinsic kinase and endoribonuclease activities and plays a key role in altering gene expression in response to endoplasmic reticulum-based stress signals. ERN1 senses unfolded proteins in the ER lumen, leading to enzyme auto-activation; the active endoribonuclease domain splices XBP1 mRNA, generating a new C-terminus and converting it into a potent unfolded-protein response transcriptional activator, triggering growth arrest and apoptosis.

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USP14

References in periodicals archive ?

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.

The effect of heat stress on frame switch splicing of X-box binding protein 1 gene in horse

The present results demonstrated that treating HUVECs with NAC down-regulated the phosphorylation of IRE1[alpha], and the IRE1 a inhibitor (STF-083010) reduced apoptosis of HUVECs as detected by TEM and flow cytometry.

Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis

The findings have revealed shown for the first time that IRE1, a cellular stress sensor that normally acts to alleviate shortterm stresses within cells, such as lack of nutrients or oxygen, is a central driver of treatment-related relapse.

Breakthrough in fight against breast cancer; Irish team develops targeted therapy

Its lead program is a first-in-class, small molecule, IRE1? inhibitor.

Quentis Therapeutics Names Jeanne Magram, Ph.D. as Chief Scientific Officer

The stress relief mechanism UPR can be initiated by ER stress sensor IRE1 upon the accumulation of misfolded or unfolded proteins.

The 95th Annual Academy of Science Meeting

Three ER-resident proteins have been identified as sensors of ER stress: IRE1 (inositol-requiring protein 1), PERK (PKR- (double-stranded RNA-dependent protein kinase) like ER kinase), and ATF6 (activating transcription factor) [11].

Transglutaminase 2 Induces Deficits in Social Behavior in Mice

Bertolotti et al., "Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1," Science, vol.

Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors

Kamphuis et al., "A J-protein co-chaperone recruits BiP to monomerize IRE1 and repress the unfolded protein response," Cell, vol.

Cellular Stress Responses and Gut Microbiota in Inflammatory Bowel Disease

There are two IRE1 genes (IRE1[alpha] and IRE1[beta]), but only IRE1[alpha] is expressed ubiquitously.

The Effect of Chronic Inflammation and Oxidative and Endoplasmic Reticulum Stress in the Course of Metabolic Syndrome and Its Therapy

The UPR, known to be a crucial defensive mechanism in ER stress, is mediated by three transmembrane proteins (IRE1, protein kinase R-like endoplasmic reticulum kinase, and activating transcription factor 6).

Vitamin D Ameliorates Impaired Wound Healing in Streptozotocin-Induced Diabetic Mice by Suppressing Endoplasmic Reticulum Stress

The UPR depends on three resident sensors: inositol-requiring transmembrane kinase/endoribonuclease 1 (IRE1), protein kinase R- (PKR-) like endoplasmic reticulum kinase (PERK), and activating transcription factor-6 (ATF6) [15, 16].

Endoplasmic Reticulum Stress Markers and Their Possible Implications in Leprosy's Pathogenesis

This UPR pathway is mainly initiated by ER stress sensors: PERK, ATF6 and IRE1, and the PERK-eIF2[alpha] and IRE1-TNF receptor-associated factor 2 (TRAF2)-Jun N-terminal kinase (JNK) pathways are the leading regulators for autophagy induction.