GRB10

(redirected from IRBP)
Also found in: Acronyms.

GRB10

A gene on chromosome 7p12.2 that encodes an adapter protein which binds to, and suppresses signals from, activated receptors tyrosine kinases—e.g., insulin and insulin-like growth factor receptors (INSR and IGF1R, respectively)—by either interfering with the signalling pathway or increasing receptor degradation. It also downregulates Wnt signalling by interfering with the binding of AXIN1 to LRP6, and it may inhibit NEDD4-mediated degradation of KDR/VEGFR-2. GRB10 upregulates the KDR/VEGFR-2 signalling pathway.
References in periodicals archive ?
obs] was for the IRBP locus between the Cote-Nord and Zecs populations (P = 0.
IRBP will take appropriate steps to punch Remune across the goal line towards approval and will have a response for the government.
Part I of the project entails laying of 61 km of 20 inch diameter loopline between Shaikarpur and Larkana in order to be able to pig and clean the 18 inch IRBP in segments.
IRBP met with the Seppic executives & Seppic has agreed to donate the IFA adjuvant for the commercial manufacturing of Remune HIV/AIDS vaccine.
There remains substantial disagreement as to which taxon (or group) is most closely related to Euneomyini; analyses that include only Cytb and IRBP sequence data tend to suggest that this tribe forms a group (in some cases, with strong Bayesian but poor bootstrap support) with Chinchillula, followed by a clade that includes Andinomys and Punomys (e.
Aun asi, es remarcable que en analisis basados en IRBP los generos andinos Aepeomys, Rhipidomys y Thomasomys forman un clado con el ampliamente distribuido--Andes, Amazonia, Selva Atlantica--Rhagomys (vease D'Elia et al.
IRBP is committed to manufacturing the Remune vaccine & the required three commercial lot batches to secure marketing authorization in the U.
The FDA & SBA waived the filing fee for the Remune BLA in early 2014 & IRBP submitted its BLA for therapeutic HIV/AIDS vaccination treatment on December 19th 2014.
IRBP Announced Plans for a New Pediatric Remune Phase II Study & FDA Breakthrough Designation Application IND to be filed with FDA
Phylogeny of Neotropical oryzo myine rodents (Muridae: Sigmodontinae) based on the nuclear IRBP exon.