IRAK2

IRAK2

A gene on chromosome 3p25.3 that encodes interleukin-1 receptor (IL1R)-associated kinase 2, one of two putative serine/threonine kinases which associate with IL1R after stimulation. IRAK2 is partially responsible for IL1-induced upregulation of transcription factor NF-kappa B.
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Recently, IRAK2 was shown to play a central role in TRAF6 ubiquitination [18].
Lin et al., "MicroRNA-146a feedback inhibits RIG-I-dependent type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2," Journal of Immunology, vol.
Additionally, miR-146 has been involved in the regulation of the genes that codify for interleukin-1 receptor-associated kinase 1 and 2 (IRAK1 and IRAK2); such proteins are involved with a functional role in toll-like receptor (TLR) signaling and cellular activation [4].
Ingenuity canonical pathways P value Affected molecules Role of macrophages, 1.15E-04 TLR2, IL1R2, SOCS3, fibroblasts, and WNT10A, STAT3, endothelial cells in rheumatoid arthritis IL17RA, and IRAK2 Inhibition of matrix 4.07E-04 MMP7, TIMP1, and A2M metalloproteases IL-6 signalling 9.12E-04 IL1R2, SOCS3, STAT3, and A2M IL-10 signalling 2.04E-03 IL1R2, SOCS3, and STAT3 Growth hormone signalling 2.14E-03 SOCS3, STAT3, and A2M IL-22 signalling 3.55E-03 SOCS3, STAT3 Role of JAK family 3.89E-03 SOCS3, STAT3 kinases in IL-6-type cytokine signalling IL-9 signalling 6.31E-03 SOCS3, STAT3 Role of JAK2 in hormone- 7.41E-03 SOCS3, STAT3 like cytokine signalling Tetrahydrobiopterin 1.10E-02 GCH1 biosynthesis I Table 2: Top 10 canonical pathways identified using IPA (upregulated by HXJD).
Likewise, TLR4 could play a role in Notch signaling pathway to regulate IRAK2, eif4E, and NF-[kappa]B, activating the RBP-J signal.
The MyD88 protein couples with IRAK4 and leads to the activation of IRAK1 and IRAK2, (20, 21) causing downstream phosphorylation and activation of nuclear factor-[kappa] B, (22) thus promoting cell proliferation.
Meanwhile, miR-195 targets the Irak2 gene, which is involved in apoptosis signaling, and the Rockl gene, which is involved in WNT signaling.
Dependiendo de la naturaleza del adaptador que se emplee, este se une a la cinasa asociada al receptor de IL-1 (IRAK4, IRAK1, IRAK2, TBK1 y IKKs), las cuales, a su vez, se unen al factor asociado al receptor del TNF-6 (TRAF-6) para activarlo y estimular a TAK1; esta cinasa pone en marcha la senalizacion por la proteina cinasa MAKK, quien fosforila a otras cinasas como JNK para generar la activacion y translocacion de factores nucleares como el PA-1 y el NF-kB, con la consecuente transcripcion de genes que codifican para citoquinas proinflamatorias.
Then interleukin-1 receptor-associated kinase-1 and -2 (IRAK1, IRAK2) is recruited to the receptor through MyD88, becomes phosphorylated and is rapidly degraded (17).
Afterwards, the death domain of Myd88 recruits IL-1 receptor-associated kinase 4 (IRAK4) and activates one of other IRAK family members, that is, IRAK1 or IRAK2. Then, IRAKs dissociate from the My88IRAK complex and activate TNF receptor-associated factor 6 (TRAF6), which interacts with transforming growth factor-[beta]-activated kinase 1 (TAK1), TAK1-binding protein 1 (TAB1), and TAB2 [33].
After TLRs engage with PAMPs, the IL-1 receptor-associated kinases IRAK4, IRAK1, IRAK2, and IRAK-M are recruited by MyD88 [29].