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IPSIDImmunoproliferative small intestinal disease Mediterranean lymphoma, α heavy chain disease A heterogeneous group of conditions characterized by monoclonal ↑ in production of Ig–usually α heavy chain, without accompanying light chains, ie 'truncated' immunoglobulins Clinical Malabsorption, diarrhea, weight loss, abdominal pain–due to marked expansion of the proximal small intestine and mesenteric lymphoid tissue, clubbing of fingers, toes Treatment Without antibiotic therapy–eg, tetracycline, IPSID may evolve to lymphoma or B cell immunoblastic sarcoma
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
immunoproliferative small intestinal disease.
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