IPF


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IPF

IPF

Abbreviation for idiopathic pulmonary fibrosis.

fraction

(frak'shon) [L. fractio, act of breaking]
1. In biological chemistry, the separable part of a substance such as blood or plasma.
2. The ratio of a component to the total, e.g., the substance fraction of carboxyhemoglobin (relative to the total hemoglobin).

attributable fraction

The percentage of instances of an illness that can be accounted for by a particular risk factor. For example, people exposed to asbestos have a certain risk of developing lung cancer, and if they also smoke tobacco, they are also at risk from that factor. These risks may be estimated from cohort studies.
Synonym: additional risk; attributable risk

carboxyhemoglobin fraction

The percentage of total hemoglobin in a blood sample that is covalently bonded to carbon monoxide.

ejection fraction

Abbreviation: EF
In cardiac physiology, the percentage of the blood emptied from the ventricle during systole. The left ventricular ejection fraction averages 60% to 70% in healthy hearts but can be markedly reduced if part of the heart muscle dies (as after myocardial infarction) or in cardiomyopathy or valvular heart disease.

immature platelet fraction

Abbreviation: IPF
The percent of platelets found in the circulating blood that still retains RNA. It is elevated (greater than 12%) in diseases in which platelets are rapidly destroyed after their release from the bone marrow, e.g., disseminated intravascular coagulation (DIC), idiopathic thrombocytopenic purpura (ITP), and thrombotic thrombocytopenic purpura (TTP). These diseases can be distinguished from other thrombocytopenic conditions in which platelet regeneration is slower, e.g., aplastic anemia, liver failure, or kidney failure, because the IPF is usually less than 12% in diseases characterized by bone marrow inactivity or suppression. The IPF is determined using flow cytometry.

fraction of inspired oxygen

Abbreviation: Fio2
The concentration of oxygen in the inspired air, esp. that supplied as supplemental oxygen by mask or catheter.

mass fraction

The ratio of the mass of a constituent to the total mass of the system in which the constituent is contained.

methemoglobin fraction

The fraction of the hemoglobin in the blood in which ferrous iron has been oxidized to ferric iron.

oxyhemoglobin fraction

F O2Hb
That portion of hemoglobin present in a sample of blood that is reversibly bound to oxygen.

plasma protein fraction

A standard sterile preparation of serum albumin and globulin obtained by fractionating blood, serum, or plasma from healthy human donors and testing for absence of hepatitis B surface antigen. It is used as a blood volume expander.

substance fraction

The ratio of the amount (number of moles or entities) of a constituent of a mixture to the total of constituents of the system.
See: mass fraction

volume fraction

The ratio of the volume of a constituent to the volume of the whole. In practice, it may be difficult to determine the volume fraction because differences in the molecular sizes of the constituents may produce a total volume that differs from the sum of the individual volumes of the mixture. When materials of similar physicochemical characteristics (such as multiple aqueous solutions) are combined, this is not a problem.

immature platelet fraction

Abbreviation: IPF
The percent of platelets found in the circulating blood that still retains RNA. It is elevated (greater than 12%) in diseases in which platelets are rapidly destroyed after their release from the bone marrow, e.g., disseminated intravascular coagulation (DIC), idiopathic thrombocytopenic purpura (ITP), and thrombotic thrombocytopenic purpura (TTP). These diseases can be distinguished from other thrombocytopenic conditions in which platelet regeneration is slower, e.g., aplastic anemia, liver failure, or kidney failure, because the IPF is usually less than 12% in diseases characterized by bone marrow inactivity or suppression. The IPF is determined using flow cytometry.
See also: fraction
References in periodicals archive ?
The IPF treatment market in the Americas has further been branched into North America and Latin America, with the North American market divided into the US and Canada.
The diagnosis of IPF was established by experienced clinical physicians and radiologists, according to the ATS diagnostic criteria.[10] Pedigree analysis revealed an autosomal dominant mode of inheritance as shown in [Figure 1].
AcAaAcAaA Acid reflux (gastroesophageal reflux disease [GERD]): Approximately 75% of people with IPF have symptoms of acid reflux or heartburn.
The overall survival of the IPPFE and IPF groups was compared using the GAP (gender, age, and physiology) index and staging system [15].
Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating, and ultimately fatal disease characterized by a progressive decline in lung function.
The researchers have talked to the FDA and will apply for a clinical trial in patients with IPF.
The American Thoracic Society/European Respiratory Society Statement on Update of the International Multidisciplinary Classification of the Idiopathic Interstitial Pneumonias 2013 was used in the diagnosis and classification of ILD.11 Interstitial lung diseases were classified into different categories including IPF, non-specific interstitial pneumonitis (NSIP), hypersensitivity pneumonitis (HP), cryptogenic organising pneumonia (COP), sarcoidosis, connective tissue disease-associated interstitial lung disease (CTD-ILD) and other rare interstitial lung diseases depending upon the patient's clinical presentation, laboratory investigations, lung function tests, environmental exposures, radiological findings and pathological diagnosis if available.
Over the last decade, more and more studies have been performed to find potential biomarkers for the prediction of IPF. Through microarray profiles, IPF has been reported to be interrelated with multiple putative miRNAs, including miR-92a [6], miR-210 [7], miR-29 [8], miR-326 [9], miR-98 [10], and miR-let-7d [11].
IPF is usually diagnosed via a hospital CT scan or by using a microscope to view a lung biopsy sample.
IPF causes continuous scarring of the lungs, making it increasingly difficult for a person to breathe.
The BLF has now taken the decision to put PS300,000 into IPF research over the next 12 to 18 months, a quarter of the PS1.2m on average it spends annually on research.