ITPR2

(redirected from IP3R2)

ITPR2

A gene on chromosome 12p11 that encodes an intracellular receptor for a so-called second messenger (inositol 1,4,5-trisphosphate (IP3)) which, once stimulated by IP3, mediates calcium release from the endoplasmic reticulum. The three IP3 receptor subtypes—IP3R1, IP3R2 and IP3R3—are present in the wild as homo- and heterotetramers, are associated with calmodulin and FK506-binding protein, and are modulated through phosphorylation by PKA, PKC, PKG and CaMKII. ITPR2 and ITPR3 are thought to play a role in exocrine secretion during metabolism and growth.
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They used genetically engineered animals lacking a receptor called type 2 inositol 1,4,5-trisphosphate (IP3R2), which astrocytes rely on to release calcium for communication.
In each case, mice lacking IP3R2 showed the same ability to learn as normal mice.
"The mice lacking the IP3R2 receptor performed much worse."
Cav1.2 and Cav1.3 were distributed on cellular membrane and cytoplasm as IP[sub]3R1, IP[sub]3R2, IP[sub]3R3, and RyR2 in both groups, but positive staining of Cav1.2, IP3R1, IP3R2, and RyR2 were not uniform in achalasia.