ITPR1

(redirected from IP3R)
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ITPR1

A gene on chromosome 3p26.1 that encodes an intracellular receptor for a so-called second messenger (inositol 1,4,5-trisphosphate (IP3)) which, once stimulated by IP3, mediates calcium release from the endoplasmic reticulum. The three IP3 receptor subtypes—IP3R1, IP3R2 and IP3R3—are present in the wild as homo- and heterotetramers, are associated with calmodulin and FK506-binding protein, and are modulated through phosphorylation by PKA, PKC, PKG and CaMKII.

Molecular pathology
IPTR1 mutations cause spinocerebellar ataxia type 15.
References in periodicals archive ?
2-Aminoethoxydiphenyl borate (2-APB), IP3Rs blocker, ryanodine, and TG did not inhibit [Ca.sup.2+] elevation, and an increase was observed at 40 and 60 [micro]M in K562 cells without DFO (Figure 3F).
CHOP/GADD153 leads to excessive production of reactive oxygen species (ROS) within ER, subsequent depletion of reduced glutathione (GSH) and [Ca.sup.2+] flux from the ER to cytoplasm through the IP3R [75].
The research team, comprising of scientists from Seoul National University, Gyeongsang National University, and Emory University in Atlanta, said that calcium plays a primary role in spreading glioblastoma tumour cells in humans, and that IP3R directly contributes to the amount of calcium released.
They discovered a sub-type of IP3R, or IP3R3, to be very active among brain cancer patients and that caffeine stymies the spread of such compounds, resulting in less tumour growth in the brain and blocks cancer cells from spreading to other parts of the body, reports Xinhua.
The function of status of intracellular [Ca.sup.2+] stores is controlled by ryanodine receptor (RyR) channels, inositol triphosphate receptor (IP3R) channels, and sarcoendoplasmic reticular [Ca.sup.2+] ATPases (SERCA) [1, 36].
Burdyga, "Evidence that NO/cGMP/PKG signalling cascade mediates endothelium dependent inhibition of IP3R mediated [Ca.sup.2+] oscillations in myocytes and pericytes of ureteric microvascular network in situ," Cell Calcium, vol.
These proteins include [Ca.sup.2+] ion channels located at the ER or at the outer mitochondrial membranes (OMM) like the Inositol 1,4,5 trisphosphate Receptor (IP3R) [79] and voltage-dependent anion channel 1 (VDAC1) [80], enzymes of the lipid biosynthetic pathways, and lipid transfer proteins [81], as well as various chaperones like the Glucose-regulated protein 75 (Grp75) [82].