ITPR1

(redirected from IP3 receptor)

ITPR1

A gene on chromosome 3p26.1 that encodes an intracellular receptor for a so-called second messenger (inositol 1,4,5-trisphosphate (IP3)) which, once stimulated by IP3, mediates calcium release from the endoplasmic reticulum. The three IP3 receptor subtypes—IP3R1, IP3R2 and IP3R3—are present in the wild as homo- and heterotetramers, are associated with calmodulin and FK506-binding protein, and are modulated through phosphorylation by PKA, PKC, PKG and CaMKII.

Molecular pathology
IPTR1 mutations cause spinocerebellar ataxia type 15.
References in periodicals archive ?
Since 1997, we were studying 2-aminoethyl diphenylborinate (2-APB) analogues to find IP3 receptor inhibitor and regulate IP3-induced calcium release [106-128].
2+] release from the intracellular endoplasmic reticulum through IP3 receptor, (36) and [Ca.
IP3 is used for signal transduction in biological cells via the release of calcium from the endoplasmic reticulum via the IP3 receptor (IP3R).
This is important, Montminy says, because the team also discovered that activity of the IP3 receptor and calcineurin in the liver are increased in diabetic insulin resistance, resulting in more blood sugar.
The results in our study, however, have not identified a specific site for the inhibitory action of schisandrin A, for example, the phospholipase C or (and) IP3 receptors activation.