ISG15

(redirected from IP17)

ISG15

A gene on chromosome 1p36.33 that encodes a ubiquitin-like protein which binds to target proteins in response to IFN-alpha or IFN-beta stimulation. ISG15 has chemotactic activity on neutrophils and activates them, triggering their release of eosinophil chemotactic factors. It may: play a role as a trans-acting binding factor, directing ligated target proteins to bind to intermediate filaments; have autocrine, paracrine and endocrine effects, including cell-to-cell signalling, possibly by inducing IFN-gamma secretion by macrophages; respond to IFN-tau secreted by the foetus; and bind and regulate proteins involved in the release of prostaglandin F2-alpha, preventing lysis of the corpus luteum and maintaining the pregnancy.
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If you want A World of My Own (10 [pounds sterling]), write to Enid Stephenson at Fromus Press, 5 Fromus Walk, Saxmundham, Suffolk, IP17 1GG.
Family flowers only, but if desired, donations to the RNLI, Cullercoats, c/o Tony Brown's Funeral Service, Saxmundham, Suffolk, IP17 1EH NIXON (Cramlington).
DARSHAM, SUFFOLK IP17 Detached double-fronted three-bedroom period cottage with exposed beams.
Offices are located at: Snape Maltings Concert Hall, Snape, Suffolk, IP17 1SP, UK.
She can be reached at The Old Shop, The Hill, Church Road, Snape, Saxmundham, Suffolk, IP17 1RJ.