A gene on chromosome 4q21 that encodes a CXC-type chemokine that is the ligand for CXCR3, which, once bound, stimulates monocyte, natural killer and T-cell migration, and modulation of adhesion molecule expression.
A panel of cytokines (IL-6, IL-10, and TNF-[alpha]) and a panel of chemokines (IL-8, IP-10, MIG, MCP-1, and RANTES) were quantified by use of Cytometric Bead Array Kits (BD Biosciences Pharmingen) with flow cytometry.
In Phase 1 studies in healthy subjects, IMO-3100 was well tolerated and suppressed TLR7- and TLR9-mediated induction of cytokines including TNF-, IFN-, IP-10 and IL-6, consistent with the intended mechanism of action.
Oral presentation: Impact of IL28b genotype and pretreatment serum IP-10 in treatment-naive genotype-1 HCV patients treated with TMC435 in combination with peginterferona-2a and ribavirin in PILLAR study, J.
17) studied 88 SARS patients with the same chemokine panel bead array assay and confirmed activation of chemokines, including IP-10, monokine induced by interferon-[gamma] (MIG), and monocyte chemoattractant protein-1 (MCP-1).