INSL4

INSL4

A gene on chromosome 9p24 that encodes insulin-like 4 protein, a member of the insulin superfamily, which may play an important role in trophoblast development and in regulating bone formation. It is expressed in placenta, uterus and in foetal perichondrium.

Molecular pathology
INSL4 is highly expressed in early placentas and molar pregnancies, and is reduced in choriocarcinoma.
References in periodicals archive ?
Insulin-like protein 4 (INSL4), produced by the placenta, plays an important role in the inhibition of excessive placental proliferation by inducing apoptosis [30].
Webster et al., "Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth," Biology of Reproduction, vol.