hormone is a marker of testicular Leydig cells in the post-pubertal testis.
The role of the testicular factor INSL3
in establishing the gonadal position.
Involvement of insulin-like factor 3 (Insl3
) in diethylstilbestrol- induced cryptorchidism.
Loss of Insl3
: A Potential predisposing factor for testicular torsion.
Genetic alternations are 17 times more likely in boys with unilateral or bilateral UDT, including mutations in the Insl3
or RXFP2 genes.
was chosen as the model system to evaluate lactam bonds as cystine isosteres in complex peptide structures.
Gravholt, "Low INSL3
in Klinefelter syndrome is related to osteocalcin, testosterone treatment and body composition, as well as measures of the hypothalamic-pituitary-gonadal axis," Andrologia, vol.
One of these is insulin-like peptide-3 (INSL3
) which is a member of the relaxin/insulin family.
The effect on fetal testosterone production has been linked to reduced expression of steriodogenic enzymes (CYP17, CYP11a, StAR) and insulin-like 3 (INSL3
) (Wilson et al.
Under the influence of insulin-like hormone 3 (INSL3
), the testes are pulled caudally by the gubernaculum, finally coming to rest in the lower abdomen at the internal ring, the developing internal entrance to the inguinal canal (Hutson et al., 2013).
Elle debute entre la 8[sup.e] et la 15[sup.e] semaine de gestation par le transit intra-abdominal, controle principalement par l'hormone insulin-like 3 (INSL3
) et son recepteur couple a la proteine-G riche en motifs leucine repetee 8 (LGR8), et se poursuit au cours du 7[sup.e] mois de gestation par la migration inguinoscrotale sous influence hormonale androgenique[sup.1].