INSL3


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INSL3

A gene on chromosome 19p13.2-p12 that encodes an insulin-like hormone produced in gonadal tissue which may be involved in the development of urogenital tract and female fertility, as well as regulate growth and differentiation of the gubernaculum, thereby mediating intra-abdominal testicular descent.

Molecular pathology
INSL3 mutations may be associated with cryptorchidism.
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References in periodicals archive ?
The INSL3 hormone is a marker of testicular Leydig cells in the post-pubertal testis.
Involvement of insulin-like factor 3 (Insl3) in diethylstilbestrol- induced cryptorchidism.
Loss of Insl3: A Potential predisposing factor for testicular torsion.
Genetic alternations are 17 times more likely in boys with unilateral or bilateral UDT, including mutations in the Insl3 or RXFP2 genes.
INSL3 was chosen as the model system to evaluate lactam bonds as cystine isosteres in complex peptide structures.
Gravholt, "Low INSL3 in Klinefelter syndrome is related to osteocalcin, testosterone treatment and body composition, as well as measures of the hypothalamic-pituitary-gonadal axis," Andrologia, vol.
The effect on fetal testosterone production has been linked to reduced expression of steriodogenic enzymes (CYP17, CYP11a, StAR) and insulin-like 3 (INSL3) (Wilson et al.
Under the influence of insulin-like hormone 3 (INSL3), the testes are pulled caudally by the gubernaculum, finally coming to rest in the lower abdomen at the internal ring, the developing internal entrance to the inguinal canal (Hutson et al., 2013).
Elle debute entre la 8[sup.e] et la 15[sup.e] semaine de gestation par le transit intra-abdominal, controle principalement par l'hormone insulin-like 3 (INSL3) et son recepteur couple a la proteine-G riche en motifs leucine repetee 8 (LGR8), et se poursuit au cours du 7[sup.e] mois de gestation par la migration inguinoscrotale sous influence hormonale androgenique[sup.1].