OCRL

(redirected from INPP5F)

OCRL

A gene on chromosome Xq25 that encodes phosphatidylinositol polyphosphate 5-phosphatase, an enzyme involved in actin polymerisation and possibly also in lysosomal membrane trafficking.

Molecular pathology
OCRL mutations cause oculocerebrorenal syndrome of Lowe and Dent disease.
References in periodicals archive ?
Wang et al., "Gene-silencing screen for mammalian axon regeneration identifies Inpp5f (Sac2) as an endogenous suppressor of repair after spinal cord injury," The Journal of Neuroscience, vol.