INK4D | definition of INK4D by Medical dictionary
CDKN2D (redirected from INK4D)
CDKN2D A gene on chromosome 19p13 that encodes a member of the INK4 family of cyclin-dependent kinase inhibitors, which form a complex with CDK4 and CDK6, preventing activation of CDK kinases and thus acting as cell growth regulators by controlling cell cycle progression through G1. CDKN2D inhibits neuronal proliferation, as well as spermatogenesis.
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References in periodicals archive
Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1mediated p19 (INK4d
) expression during odontogenesis.
CDK activity is regulated by 2 families of inhibitors: INK4 proteins, including INK4A (p16), INK4B (p15), INK4C (p18), and INK4D
(p19), and the Cip and Kip family, which is composed of p21 (Cipl), p27 (Kipl), and p57 (Kip2) (5), (8).