CDKN2C

(redirected from INK4C)

CDKN2C

A gene on chromosome 1p32 that encodes a member of the INK4 family of cyclin-dependent kinase inhibitors, which form a complex with CDK6 and to a lesser extent with CDK4, preventing activation of CDK kinases and thus acting as cell growth regulators by controlling cell cycle progression through G1. CDKN2C inhibits cell growth and proliferation with dependence on endogenous retinoblastoma protein.
References in periodicals archive ?
Hematopoietic stem cell exhaustion impacted by p18 INK4C and p21 Cip1/Waf1 in opposite manners.