Molecular analysis of the INK4A and INK4B
gene loci in human breast cancer cell lines and primary carcinomas.
Spandidos, "Deregulation of the tumour suppressor genes p14ARF, p15 INK4b
, p16INK4a and p53 in basal cell carcinoma," British Journal of Dermatology, vol.
gene methylation in acute lymphoblastic leukemia and its pronostic value.
Vereecque et al., "Methylation of the p15(INK4b
) gene in myelodysplastic syndromes is frequent and acquired during disease progression," Blood, vol.
Moreover, depletion of ANRIL disrupts the binding of suppressor of zeste 12 protein homolog (Suz12), a component of PRC2, to INK4B
locus, and increases the expression of p15 [49, 50].
Methylation of the p15(INK4B
) gene in myelodysplastic syndrome: It can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation.
) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing.
)/p16(INK4a)/RB1 pathway is frequently deregulated in human pituitary adenomas.
CDK activity is regulated by 2 families of inhibitors: INK4 proteins, including INK4A (p16), INK4B
(p15), INK4C (p18), and INK4D (p19), and the Cip and Kip family, which is composed of p21 (Cipl), p27 (Kipl), and p57 (Kip2) (5), (8).
Immunohistochemical expression of P15 (INK4B
) and SMAD4 in advanced gastric cancer.
Methylation of the p15 (INK4B
) gene in myelodysplastic syndromes is frequent and acquired during disease progression.
Amongst genes frequently implicated in HBV-induced epigenetic suppression are p14 (ARF), pl5 (INK4B
), p16 (INK4A), and pRB [87, 119, 120].