CDKN2B

(redirected from INK4B)

CDKN2B

A gene on chromosome 9p21 that encodes a member of the INK4 family of cyclin-dependent kinase inhibitors, which form a complex with CDK4 or CDK6, preventing activation of CDK kinases and thus acting as cell growth regulators by controlling cell cycle progression through G1. CDKN2B expression is dramatically induced by TGF beta, suggesting a role in TGF-beta-induced growth inhibition.
References in periodicals archive ?
p15 INK4B gene methylation in acute lymphoblastic leukemia and its pronostic value.
Alterations of INK4A and INK4B genes in adult soft tissue sarcomas: effect on survival.