SMARCB1

(redirected from INI1)

SMARCB1

A gene on chromosome 22q11.23 that encodes a core component of the ATP-dependent chromatin-remodelling BAF (hSWI/SNF) complex, which plays key roles in cell proliferation and differentiation and has antiviral and anti-tumour activity.

Molecular pathology
Defects in SMARCB1 rhabdoid tumour predisposition syndrome type 1, schwannomatosis and mental retardation, autosomal dominant type 1.
References in periodicals archive ?
3) Our patient's immunohistochemistry demonstrated S-100 protein positivity and loss of INI1, consistent with EMPNST.
The latter entity was recently distinguished from sinonasal carcinoma by the loss of INI1 and the basaloid/rhabdoid morphology.
A panel comprising PAX8, p63, and INI1 is most optimal for distinguishing RMC from transitional cell carcinoma and collecting duct carcinoma, as all these tumors show a similar staining pattern with CK7 and vimentin.
Gracias a la clara relacion de este tumor con la presencia de alteraciones SMARCB1/ INI1 desde el 2004 se introdujo la medicion de anticuerpos dirigidos contra este supresor tumoral como rutina dentro del proceso diagnostico (10).
1] However, specific immunohistological markers, in particular INI1, have made it possible to differentiate these tumours from PNETs in cases where primitive cells predominate.
Chemotherapy consisted in the European Soft Tissue Sarcoma Study Group (EpSSG) extracranial rhabdoid tumor protocol (carboplatin, vincristine, cyclophosphamide with doxorubicin, ifosfamide, and etoposide) because institutional pathologic examination concluded to a rhabdoid tumor on reticular pattern of rhabdoid-like cells with absence of INI1 expression.
The common genetic basis for rhabdoid tumours is a deletion and/or mutation of the INI1 gene on chromosome 22 (22q11), inactivating the tumour suppressor gene SMARCB1, though these tumours can lack this mutation as seen in this case.
INI1 captures the degree of macroeconomic distortions and unfamiliarity with market processes in society.
Industria INI1 MDPAOAP AAA Industrial TABLE 2 Contrast of the Original and Autoregressive Models Panel A: Original Panel B: Autoregressive Model Coefficient [R.
INI1 (also known as hSNF5 and SMARCB1) is a member of the SWI/SNF chromatin remodeling complex located on chromosome band 22q11.
The company stated that MRT is a tumor defined by loss of INI1 protein as measured by immunohistochemistry.
INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma.