ING5

ING5

A gene on chromosome 2q37.3 that encodes inhibitor of growth (ING) family member 5, a component of the HBO1 complex responsible for the bulk of histone H4 acetylation in vivo. ING5 is also a component of the MOZ/MORF complex, which has histone H3 acetyltransferase activity. It may regulate DNA replication and act as a transcriptional coactivator by acetylating chromatin.
References in periodicals archive ?
Chromatin remodeling genes, such as EED, ARID1A, ING5, CTBP1, CBX3, CBX7, MTA1, and NSD1, have key roles in the carcinogenesis of GC (10, 11, 13-16).
The 8 genes, which were chosen as the most over- or underexpressed, were EED, ARID1A, ING5, CTBP1, CBX3, CBX7, MTA1, and NSD1.
The expression of ARID1A, ING5, and CBX7 genes was significantly lower in the GC group than in the control group (fold change<0.5 and fold regulation<-2).
The expression of ARID1A, ING5, and CBX7 genes was significantly lower in the AG than in the control group (fold change<0.5 and fold regulation<-2).
There were no significant differences between the expression levels of EED, CBX3, MTA1, ARID1A, ING5, and CBX7 gene between patients with AG and those with GC, although the expression level (fold change level) of these genes was higher in patients with GC than in those with AG (Table 4, 5) (Figure 4).
There were no differences related to the expression of ARID1A, ING5, and CBX7 genes between the HP-positive and HP-negative
There were no differences related to the expression of ARID1A, ING5, and CBX7 genes between the IM-positive and IM-negative AG subgroups (Table 7).
Ye et al., "ING5 suppresses breast cancer progression and is regulated by miR-24," Molecular Cancer, vol.
Lv et al., "The miR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer," Oncotarget, vol.
Wang et al., "Upregulated in Hepatitis B virus-associated hepatocellular carcinoma cells, miR-331-3p promotes proliferation of hepatocellular carcinoma cells by targeting ING5," Oncotarget, vol.
MiR-196a has been well believed to be associated with abnormal apoptosis, invasion, and proliferation of pancreatic cancer cells by downregulating ING5 expression [50].
Zhao, "ING5 inhibits epithelial-mesenchymal transition in breast cancer by suppressing PI3K/Akt pathway," International Journal of Clinical and Experimental Medicine, vol.