ING4

ING4

A gene on chromosome 12p13.31 that encodes inhibitor of growth (ING) family member 4, a component of the HBO1 complex responsible for the bulk of histone H4 acetylation in vivo. ING4 may inhibit tumour progression by downregulating signalling pathways which drive cell proliferation. It suppresses brain tumour angiogenesis through transcriptional repression of RELA/NFKB3 target genes.

Molecular pathology
Reduced expression of ING is linked to higher grades of gliomas and carcinomas of the breast, head and neck, and stomach.
References in periodicals archive ?
By scanning various tumor cells taken from patients, Igor Garkavtsev of Harvard Medical School and Massachusetts General Hospital in Boston noticed that brain cancer and kidney cancer cells seemed deficient in ING4.
They concluded that cells from slow-growing cancers had only one-half to one-third as much ING4 protein as did healthy brain cells.
Next, the researchers implanted human glioblastoma tumors into mice, some of which had functional genes that encode ING4 protein and others that had defective genes and little ING4 protein.
Tumors in mice deficient in ING4 grew faster and larger than did tumors in mice with a full complement of the protein.
Also, a shortage of ING4 permitted more new blood vessels to form around the mouse tumors, a process called angiogenesis.