ING3A gene on chromosome 7q31 that encodes inhibitor of growth (ING) family member 3, a component of the NuA4 histone acetyltransferase (HAT) complex involved in transcriptional activation of genes, principally by acetylating nucleosomal histones H4 and H2A. Acetylation alters nucleosome-DNA interactions and upregulates transcription. The NuA4- HAT complex may be required for activating transcriptional programs linked to oncogene- and proto-oncogene-mediated growth induction, tumour-suppressor-mediated growth arrest and replicative senescence, apoptosis and DNA repair. NuA4 may also play a role in DNA repair when recruited to sites of DNA damage.
Defects of ING1 have been linked to an increased susceptibility to squamous cell carcinoma of the head and neck.
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