Also found in: Acronyms.
ING1A gene on chromosome 13q34 that encodes a nuclear protein and putative tumour suppressor which induces cell growth arrest and apoptosis. It interacts with the tumour suppressor protein TP53 and is a component of the p53 signalling pathway. ING1 expression in normal and malignant tissues differs according to the isoform.
Defects of ING1 have been linked to an increased susceptibility to squamous cell carcinoma of the head and neck.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.