[UKPRwire, Thu Jul 04 2019] 6-Azauracil inhibits IMP dehydrogenase
(IMPDH) the rate-limiting enzyme in de novo GTP synthesis.
Particularly, punA, adenosine kinase, APRT, AMP deaminase, IMP dehydrogenase, GMP synthase, and guanine deaminase that were involved in purine nucleotide biosynthesis were discovered in the annotation dataset of H.
Key genes were determined by real-time PCR, and punA, IMP dehydrogenase, and GMP synthase genes involved in purine nucleotide biosynthesis were found upregulated 16.56-fold, 8-fold, and 5.43-fold, respectively.
(ii) related enzymes exhibit SI in the conditions employed, as is the case for IMP dehydrogenase , and
[2.] Sullivan, WJ, Jr, Dixon, SE, Li, C, Striepen, B and Queener, SF, "IMP dehydrogenase from the protozoan parasite Toxoplasma gondii", Antimicrobial Agents and Chemotherapy 2005; 49: 2172-2179.
Expression of IMP dehydrogenase in differentiating HL-60 cells.
Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis.
Two distinct cDNAs for human IMP dehydrogenase. J Biol Chem 1990;265:5292-5.
Assignment of the human type I IMP dehydrogenase gene (IMPDH1) to chromosome 7831.3-q32.
Modulation of IMP dehydrogenase activity and guanylate metabolism by tiazofurin (2[beta]-D-ribofuranosylthiazole-4-carboxamide).
Growth inhibition and induction of phenotypic alterations in MCF-7 breast cancer cells by an IMP dehydrogenase inhibitor.
Characterization of human type I and type II IMP dehydrogenases
. J Biol Chem 1993;36:27286-90.