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interstitial lung disorder



Any of a large group of diseases with different causes but with the same or similar clinical and pathological changes. These are due to chronic, nonmalignant, noninfectious diseases of the lower respiratory tract characterized by inflammation and disruption of the walls of the alveoli. This manifests clinically as a limitation in the ability of the lungs to transfer oxygen from the alveoli to the pulmonary capillary bed. Patients with these disorders are dyspneic first in connection with exercise and, later, as the disease progresses, even at rest.

Approximately 180 different types of ILD exist, many of which are poorly understood. Known causes include inhalation of irritating or toxic environmental agents such as organic dusts, fumes, vapors, aerosols, and inorganic dusts; drugs; radiation; aspiration pneumonia; and the consequences of acute respiratory distress syndrome. See: idiopathic pulmonary fibrosis

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References in periodicals archive ?
Treatment of RA-ILD is becoming more complicated and challenging, since almost all drugs used in the treatment of RA can cause ILD or have already mediated ILD.
In our study ILD was noted in 26.4% of patients, NSIP was the most common ILD.
(6) It is likely that the positive predictive value for a probable UIP pattern in this study would be less if patients in this study consisted of consecutive patients with varied ILDs demonstrating a probable UIP pattern instead of the IPF-enriched patient population for the ARTEMIS-IPF trial.
Most of the fibrotic ILDs carry a dismal prognosis with a median survival time for IPF of two to three years from the time of diagnosis.5-8 The diagnosis is not straightforward in most of the cases; Not surprisingly, >50% of these patients are initially misdiagnosed with other forms of respiratory illness.9,10 Timely diagnosis and early referral of patients to centres with specific expertise may lead to more optimal disease management.
In RA patients with concomitant ILD, PL-7, PL-12, and EJ antibodies were detected, with PL-7 antibodies having the highest incidence.
In addition to drug therapy, the American College of Chest Physicians recommends routine assessment of quality-of-life (QOL) concerns in patients with ILD (table).
We found that hypoxia is associated with clubbing in patients with ILD, and we presume from this that hypoxia could be responsible, to some extent, for clubbing in the study population.
There is a lack of data on ILD from developing countries.
The clinical significance of the positive anti-CCP antibody titre without apparent manifestations of RA is not clear, but it has been proposed that patients with ILD and the presence of anti-CCP antibodies are at risk of developing RA (9).
She is involved in a weekly multidisciplinary team meeting where all possible ILD cases are discussed, and where a diagnosis is made.