IL6


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IL6

A gene on chromosome 7p21 that encodes interleukin-6, a cytokine which plays a role in the acute-phase response of inflammation and in B-cell maturation. It is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through Il-6 receptor alpha.

Molecular pathology
IL6 dysfunction is linked to increased susceptibility to diabetes and juvenile rheumatoid arthritis.
References in periodicals archive ?
adiponectin and visfatin.6 In addition it also secretes inflammatory adipokines TNFa, IL6, IL1 that not only cause local steatonecrosis, but are distributed throughout the body by a vascular system resulting in a chronic inflammatory state.7
After adjusting for multiple testing, we found no significant association between any of the IL6 gene variants and IL-6 concentration.
The potential importance of monitoring indoleamines is illustrated by the results from patients with severe sepsis and septic shock who underwent extracorporeal immunoadsorption, showing that removal of LPS, IL6, and C5a both beneficially influenced the overall progress of the study patients (22) and restored Trp and 5-HT concentrations within five days of treatment.
Finalmente, para descartar la presencia de confusion, se estimaron modelos de regresion binomial para tener niveles elevados de IL6 o PCR segun los limites definidos atras (modelo que genera razones de prevalencia -RP), asi como de regresion lineal para los niveles normalizados de ambas sustancias.
Further, SMAD1 overexpression could reverse the FBXW7[alpha] siRNA enhanced IL6, IL12p40, and TNF[alpha] production significantly (Figure 4E-4G).
Taking these many factors into account, the genes encoding key interleukins, such as IL1B and IL6 as well as interleukin receptor IL6R, were chosen as candidate genes for association with soft tissues injuries.
Furthermore, studies have suggested that overproduction of IL6 and IL-8 may induce thrombopoiesis, neutrophil migration, and myxoma cell fragment adhesion to coronary artery endothelium, leading to myocardial ischemia and infarction.
Immunopathogenesis involves interplay of IL1 and IL6 mediated inflammation of macrophages along with reactive thrombocytosis and anaemia.
Although experiments done to study cellular effects of leptin have reported it to induce the inflammatory markers like TNF[alpha], IL6 and reactive oxygen species etc and reported it to be correlated with CAC scores as an indicator of subclinical atherosclerosis.
We evaluated the mRNA expression of the following proinflammatory cytokine [interleukin-1a (IL1A), interleukin-6 (IL6), interleukin-8 (IL8) and tumour necrosis factor (TNF)] and bone formation [alkaline phosphatase (ALP), collagen type 1 (COL1) and runt-related transcription factor 2 (RUNX2)] genes.
After AP induction, KO mice for IL6, (7) OPN, (8) iNOS, (9) TLR22, (10) IL17RA; (11) MyD88 (12) and MMP9 (13) developed more severe AP than wild-type mice; on the other hand, KO mice for I[l.sub.2]2 (32) and for CB2 (33) developed less severe AP.