Variations in the TNFalpha gene and their interactions with the IL4R
and IL10 genes in relation to hand osteoarthritis.
NAFLD&NASH to HCC PBC&PSC to HCC The highly activated ACTA2, AIFM1, APP, ACTB, ADRB2, APP, network biomarkers EGFR, GRB2, NEDD8, CSNK2A1, EGFR, for potential SHC1, TUBA1C, TUBB6, HUWE1, LMNB1, PCK1, inhibition strategy IL4R
, GPR37, FRAT2, PPP2CA, SMAD5, of drug design HIST2H2BE, HSPB1, TSC22D1, ESR1, PGR, ZNF480, TIMP1, RYR2, FRAT2, ALDOB, ZYX, YBX1, HIST2H2BE, ZNF480, TP53, STAT5A, AR, H3F3A, TIMP1, ALDOB, TELO2, PXN, TBP, IGF2, AR, TP53, SRF, REPIN1, HSF1, ETS1, NRF1, STAT5A, STUB1, RFC5, RPL30, RPL23A, SP1, SP3, TRMT1, GSK3B, UBC, CEBPA, BPTF, ETS1, ALB, and MIR21 MDC1, RFC5, RPL30, TRMT1, UBC, GSK3B, TF, and MIR21 The repressed ALK and GATA1 CEBPE and GATA1 network biomarkers for potential activation strategy of drug design
Secondary outcome measures include progression-free survival, overall survival, and exploratory predictors of outcome assessed by IL4R
expression in archived tumor biopsies.
These results might further explain the beneficial effects exerted by miR-125b inhibition in SOD1-G93A microglia and motor neuron survival, thus suggesting that the neuroprotective effect exerted by miR125b inhibition might depend not only on the suppression of toxic mediators among which IL-1[beta] (Figure 2(a)), TNF[alpha], and NOX2 , but also on the direct stimulation of M2 parameters such as IL4R
, Arg1, and BDNF in ALS microglia.
Asthma is believed to have a strong genetic background, and hundreds of genes have been identified to be related with asthma, including GSTM1, IL10, CTLA-4, SPINK5, LTC4S, IL4R
, and ADAM33 .
Molecule Group/fold changes Willow Ethanol Imipramine bark fraction IL3 -4.3 -1.1 -3.4 IL10 -2.2 1.1 -4.3 IL15 1.2 1.1 2.0 IL13RA1 2.6 1.8 2.5 IL13RA2 - - 14.8 IL17RA -2.7 -1.4 -1.5 IL1[beta] 2.3 -2.1 1.4 IL1RL2 - - -9.1 IL20RB -4.7 - -3.3 IL21R 2.1 1.2 1.5 IL22RA2 1.9 6.1 2.0 IL4R
-1.9 1.1 -2.7 IL7R 3.1 1.3 2.3 TNFAIP2 - - -2.2 TNFRSF1A -2.7 -1.1 1.5 TNFSF12 1.5 -1.7 -2.1 TNFSF14 3.0 1.6 -1.0 Bold: statistically significant values (p <0.01), IL: interleukine, R: receptor, TNFSF: tumor necrosis factor a-superfamily.
To illustrate this, a 1362-bp fragment corresponding to a part of the IL4r
gene from an individual heterozygous at six different positions was prepared by incorporation of R110-dUTP during PCR (31).
The genetic variants of pro-inflammatory cytokines (IL4, IL13, IL10, IL18, TNF, and IFNGR1), the cytokine receptor (IL4R
), the genes involved in the IgE/Fc[epsilon]RI pathway (the galectin-3 gene (LGALS3)), and nucleotide-binding oligomerization domain (NOD) gene polymorphisms are also strongly associated with betalactam-induced immediate reactions (Table 2) [67-73].
The following search terms were used: "interleukin4", "interleukin 4", "IL-4", "Interleukin-4 receptor", "IL4R
", "periodontitis", "periodontal disease", and "polymorphism".
Assays used were as follows: TBP (endogenous control), Hs99999910_m1; CXCL16, Hs00222859_m1; IL4R
, Hs00166237_m1; JUN, Hs00277190_s1; PF4, Hs00427220_g1; PTPRE, Hs00369944_m1; ZNF331, Hs00367929_m1.
Remarkably, Th17-lymphocyte-related genes and transcripts that can modulate Th17 cell development and functions were overexpressed including IL4R
, IL2RG, IL6ST, IL1B, IL7R, STAT6, STAT5B, SOCS3, and CXCL2.
Plenty of inflammatory DEGs in EC were upregulated, such as NFKB1, IL2RG, IL6, IL6R, IL4R
, IL7, JUND, TGFBR1, TGFB2, and TGFB3.