IL31 | definition of IL31 by Medical dictionary
IL31 A gene on chromosome 12q24.31 that encodes interleukin-31, an immunomodulatory cytokine which activates STAT3, and possibly STAT1 and STAT5, through the IL31 receptor, which is composed of a heterodimer of IL31RA and OSMR. IL31 may play a role in skin immunity.
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References in periodicals archive
Our result is also in an agreement with the previous finding by others that IL31
is highly effective in suppressing the proliferation of lung epithelial cells .
Kim, "Transcriptional activation of the IL31
gene by NFAT and STAT6," Journal of Leukocyte Biology, vol.
Bruder et al., "Correlation of IL31
serum levels with severity of atopic dermatitis," Journal of Allergy and Clinical Immunology, vol.
In both AR and AAR the levels of IL31
and IL-33 positively correlated.