IL28B

IL28B

A gene on chromosome 19q13.13 that encodes interleukin-28B, an immunomodulatory cytokine which upregulates MHC class-I antigen expression. It has potent antiviral activity and has antitumour activity. IL28B is a ligand for the heterodimeric class-II cytokine receptor composed of IL10RB and IL28RA, which is thought to act via the JAK-STAT pathway. Difference between the two isoforms of IL28 (IL28A and IL28B) remains unclear.
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Real world experience with pegylated interferon and ribavirin in hepatitis C genotype 1 population with favourable IL28B polymorphism.
HLA-DP and IL28B polymorphisms: influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B.
Although some of these studies had been performed before IL28B genotyping was recommended, this difference in response rates might be explained with differences in gene polymorphisms.
IL28B gene polymorphism SNP rs8099917 genotype GG is associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-1 carriers.
Indeed, we have recently found that allele and genotype frequencies at IL28B locus of Uruguayan individuals closely resemble those of an admixed population rather than a uniformly European-descendant one [59].
Sacks-Davis et al., "The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection," Hepatology, vol.
Shakya et al., "Prevalence of HIV, hepatitis B and C infections and an assessment of HCV-genotypes and two IL28B SNPs among people who inject drugs in three regions of Nepal," PLoS ONE, vol.
Eilard et al., "Core mutations, IL28B polymorphisms and response to peginterferon/ribavirin treatment in Swedish patients with hepatitis C virus genotype 1 infection," BMC Infectious Diseases, vol.
Apart from that, body mass index over 30, insulin resistance, IL28B genetic polymorphism localized on chromosome 19, and advanced liver fibrosis are defined as the other negative predictive factors (6).
Association of IL28B gene Variation with Mathematical Modeling of Viral Kinetics in Chronic Hepatitis C Patients with IFN plus Ribaviral Therapy.
(80) In 2009, three independent research groups performed GWASs for chronic HCV treatment responses and the clearance of virus after acute infection, and SNPs located near the interleukin 28B (IL28B) gene, which encodes IFN-[lambda]3, showed significant associations.