Real world experience with pegylated interferon and ribavirin in hepatitis C genotype 1 population with favourable IL28B
HLA-DP and IL28B
polymorphisms: influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B.
polymorphism as a predictor of antiviral response in chronic hepatitis C.
Although some of these studies had been performed before IL28B
genotyping was recommended, this difference in response rates might be explained with differences in gene polymorphisms.
gene polymorphism SNP rs8099917 genotype GG is associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-1 carriers.
Indeed, we have recently found that allele and genotype frequencies at IL28B
locus of Uruguayan individuals closely resemble those of an admixed population rather than a uniformly European-descendant one .
Sacks-Davis et al., "The effects of female sex, viral genotype, and IL28B
genotype on spontaneous clearance of acute hepatitis C virus infection," Hepatology, vol.
Shakya et al., "Prevalence of HIV, hepatitis B and C infections and an assessment of HCV-genotypes and two IL28B
SNPs among people who inject drugs in three regions of Nepal," PLoS ONE, vol.
Eilard et al., "Core mutations, IL28B
polymorphisms and response to peginterferon/ribavirin treatment in Swedish patients with hepatitis C virus genotype 1 infection," BMC Infectious Diseases, vol.
Apart from that, body mass index over 30, insulin resistance, IL28B
genetic polymorphism localized on chromosome 19, and advanced liver fibrosis are defined as the other negative predictive factors (6).
Association of IL28B
gene Variation with Mathematical Modeling of Viral Kinetics in Chronic Hepatitis C Patients with IFN plus Ribaviral Therapy.
(80) In 2009, three independent research groups performed GWASs for chronic HCV treatment responses and the clearance of virus after acute infection, and SNPs located near the interleukin 28B (IL28B
) gene, which encodes IFN-[lambda]3, showed significant associations.