IL28A

IL28A

A gene on chromosome 19q13.13 that encodes interleukin-28A, an immunomodulatory cytokine which upregulates MHC class-I antigen expression. It has potent antiviral activity and has antitumour activity. IL28A is a ligand for the heterodimeric class-II cytokine receptor composed of IL10RB and IL28RA, which is thought to act via the JAK-STAT pathway. Difference between the two isoforms of IL28 (IL28A and IL28B) remains unclear.
References in periodicals archive ?
However, treatment with IL28A improved mices' general appearance, and completely prevented CVB3 infection-associated death up to 14 days post-infection, even with the lower dose of IL-28A (10 [micro]g/kg).
The area under theROC curvefor HCC-4was 0.73; for IL28A it was 0.79; for IL-31, it was 0.79; for MCP-2, it was 0.83; and for CXCL7 (NAP-2), it was 0.79 (Figure 1).