IL27

IL27

A gene on chromosome 16p11 that encodes interleukin-27, a pro- and anti-inflammatory cytokine that regulates T-helper cell development, suppresses T-cell proliferation, stimulates cytotoxic T-cell activity, induces isotype switching in B-cells, and which has diverse effects on innate immune cells. Its target cells include CD4 T-helper cells, which can differentiate in types 1 and 2 effector cells (TH1 and TH2), and IL17-producing helper T-cells (TH17); it drives rapid clonal expansion of naïve CD4 T-cells. It strongly synergises with IL12 to trigger interferon-gamma production by naïve CD4 T-cells and binds to the cytokine receptor WSX-1/TCCR, which appears to be required for IL27-mediated signal transduction. IL27 potentiates the early phase of TH1 response and suppresses TH2 and TH17 differentiation. It also has antitumour and antiangiogenic activity, with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. IL27 is also a less preferred gene symbol for what is now designated as IL17D, see there.
References in periodicals archive ?
The expression of CD39 in Treg lymphocytes is created by a recognition of the TCR pathway and promoted by IL-6 and IL27, which are present in the microenvironment surrounding the tumor.
Based on the literature, we thus selected a panel of miRNAs to examine their ability to augment the effects of IL27 on proinflammatory and/or proosteogenic genes.
Strains of LABs were further modified to express various anti-inflammatory complexes, including monovalent and bivalent murine TNF neutralizing antibodies, the helper-T-cell regulating IL27, and TGF-beta.
Although this study found that IL23 and IL27 transcripts significantly increased in peripheral blood of breast cancer patients, the IL-23/IL-27 ratio was significantly lower in PBMCs of breast cancer patients versus healthy volunteers which may lead to the defect in anti-tumor systemic immune responses.
Taken together, our findings indicate that IFN-[gamma] treatment may induce the changes in some cytokines in AP which are characterized by reduction in IL27 and increase in IL18.
Esta citoquina junto con la IL6 (Interleukina-6), vIL6 (Interleukina-6 viral a partir del virus herpes tipo 8) o tambien denominado virus del sarcoma de Kaposi, IL11 (Interleukina-1), OSM (Oncostatina M), CT1 (Cardiotrofina-1), CLC/BSF3 (Citoquina similar a la Cardiotrofina-1/Factor estimulante de la Linfopoyesis B tipo 3), NP (Neuropoyetina), IL27 (Interleukina-27), pertenecen a la familia de la IL6.
It is a member of the IL-12 molecule family, together with IL-21 and IL27. IL-23 is produced by DCs, and it is important for the early differentiation of human [T.sub.FH] cells.
IL-27 consists of the EBI3 and p35 components and stimulates both STAT1 and STAT3 through different IL27 receptors, the receptor subunit WSX-1 paired with the gp130 chain [143].
Kozar et al., "Crosstalk between different family members: IL27 recapitulates IFN-[gamma] responses in HCC cells, but is inhibited by IL6-type cytokines," Biochimica et Biophysica Acta, vol.
Mahnke, "Il27 renders DC immunosuppressive by induction of B7-H1," Journal of Leukocyte Biology, vol.
Vargas-Alarcoan, "Protective role of Interleukin 27 (IL27) gene polymorphisms in patients with ulcerative colitis," Immunology Letters, vol.
As shown in Figure 2(a), IL27 treatment significantly upregulated HLA-E (MRFI [+ or -] SD: medium 4.33 [+ or -] 1.95; IL-27 9.75 [+ or -] 3.31; P = 0.01) but not HLA-G expression on monocytes.