IL26

IL26

A gene on chromosome 12q15 that encodes a protein belonging to the IL10 family of cytokines thought to have a pro-inflammatory role in mucosal immunity; it is inhibited by heparin. IL26:
• Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT;
• Induces expression of SOCS3, TNF-alpha and IL-8;
• Induces secretion of IL-8 and IL-10 and surface expression of ICAM1; and
• Decreases proliferation of intestinal epithelial cells.

Molecular pathology
IL26 may play a role in inflammatory bowel disease.
References in periodicals archive ?
To assess the severity of aGvHD, special markers may be considered, such as fecal alpha-1 antitrypsin, fecal calprotectin, TIM3, sTNFR1, ST2, IL26, and Reg3alpaa (19).
Along with IL17, Th17 cells also produce IL22, IL26, and GM-CSF.
The former is specific for the IFNL receptor (IFNLR), while the latter is shared with the type II cytokine receptors for IL-10, IL-22, and IL26 [45].
In addition, the expression of 7 cytokines genes (IL-22, VEGFA, IL26, CXCL14, BMPER, IL-17D, and CCL20) and 16 receptor genes (IL-22RA1, CXCR3, IL-17RC, IL-1RAPL2, IFITM5, NRG2, TNFRSF14, LEPREL2, IL-11RA, LTBP2, ILDR1, IL-17RD, MC1R, IL-22RA2, LEPREL1, and LILRA5) were significantly downregulated by 3.6- to 5.7-fold and 2.14- to 9.12-fold, respectively with p < 0.01 and fold [greater than or equal to] 2 (Figures 4 and 5).
The cytokines secreted by Th17 cells are IL21, IL23, IL26, tumor necrosis factor a, interferon y, and mainly IL17 6].
Nearby genes implicated as possibly playing a role in ulcerative colitis include the ring finger protein 186 (RNF186), OTU domain containing 3 (OTUD3), and phospholipase A2, group IIE (PLA2G2E) - genes on chromosome 1p36, and the interferon, gamma (IFNG), interleukin 26 (IL26), and interleukin 22 (IL22) genes on chromosome 12q15 that play an important role in inflammation.
Human T17 cells express retinoic acid receptor-related orphan receptor (ROR)C and produce, besides IL-17A, also IL-17F, IL-21, IL-22, and IL26 [7, 8].
According to them, nearby genes implicated as possibly playing a role in ulcerative colitis include the ring finger protein 186 (RNF186), OTU domain containing 3 (OTUD3), and phospholipase A2, group IIE (PLA2G2E) - genes on chromosome 1p36, and the interferon, gamma (IFNG), interleukin 26 (IL26), and interleukin 22 (IL22) genes on chromosome 12q15.