IL23A

IL23A

A gene on chromosome 12q13.13 that encodes interleukin-23A, a cytokine which associates with IL-12B to form IL-23, a heterodimeric cytokine involved in innate and adaptive immunity. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the JAK-START signalling cascade, stimulates memory T cells and promotes production of proinflammatory cytokines.
 
Molecular pathology
IL-23 may induce autoimmune inflammation and play a role in tumourigenesis.
Mentioned in ?
References in periodicals archive ?
The hetero dimerized IL23 receptor constituted of specific (IL23A) and common (IL12R[beta]1) subunits [21].
Generation of IL- 23RA9 form (GenBank AM990318), which encodes a soluble version of the entire external domain of the specific receptor chain (IL23A), is an example of this splicing [28].
The expression of other Th1/Th17-related soluble factors (IL22, NFKB1, IL23A, STAT3, CCR5, IL17RA, CX3CL1, CXCL12, and CXCL5) was also assessed by RT-PCR, and the amount of mRNA calculated as above described.
To lend support to the downregulation of Th1/Th17 pathway cytokines in LPCs, other soluble factors of the same subgroups (IL22, NFKB, IL23A, STAT3, CCR5, IL17A, IL17RA, CXCL12, CX3CL1, and CXCL5) were evaluated by RT-PCR.
ADAMTS9 CRIP2 ENGASE IL23A RT1-DA AHCY CTGF ERO1LB KRT20 S100A4 AMIGO3 DDIT3 ETV5 MANF SDF2L1 ANKRD37 DERL3 FGF18 MFSD2 SEC23B ATMIN DNAJB11 FOLR1 NR4A2 SEL1L BCAM DNAJB9 GGCT NUPR1 SLIT1 BET1 DNAJC3 GMPPB PDIA4 TM4SF1 CASP4 DUOX2 HSP90B1 PRIMA1 TMEM140 CDH1 DUSP5 HSPA5 PRSS8 TMEM66 COQ10B DYNLRB2 HYOU1 RIL ZFAND2A CRELD2 ELOVL2 IGF2BP2 RIOK3 Table 3: Target genes of the transcription factor PAX8 (gene symbol) [37].
In Pam3CSK4-stimulated macrophages, silencing of lincRNA-Cox2 results in attenuated expression of 713 genes, including TLR1, IL-6, and IL23a. The regulatory effect of lincRNA-Cox2 on immune gene expression was demonstrated to associate with hnRNP-A/B and A2/B1.
With respect to PsA, it has been shown that single nucleotide polymorphisms in IL23A, IL23R as well as TRAF3IP2 (Act1), a downstream target of IL-17R, confer susceptibility to the disease (71, 72).
mRNA levels (qRT-PCR) of TNF[alpha] (a), IL6 (b), IL8 (c), IL23A (d), and IL10 (e) in the mesenteric adipose tissue (MAT) of CD patients (ACD Group) compared to controls (AC Group).
Flynn et al., "Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis," Annals of the Rheumatic Diseases, vol.
In addition to known psoriasis susceptibility loci encoding proteins engaged in the TNF-alpha, IL-23, and IL-17 signaling pathways (including HLA-Cw6, IL23R, IL12B, IL23A, and TNFAIP3 genes), IL6 and STAT3 polymorphisms have been linked with hereditary predisposition of developing psoriasis and response to TNF-alpha inhibitors [33, 86-89].
(a-c) The mRNA expression of cytokines and chemokines including IL1[alpha], IL1[beta], IL4, IL6, IL8, IL10, IL12A, IL12B, IL13, IL17A, IL17B, IL18, IL23A, IL33, TNF[alpha], IFN[beta], and TGF[beta] were determined by qRT-PCR assays.
Real-time PCR reactions were performed on an ABI 7900HT (Life Technologies) with TaqMan primer sets for murine Fizz1, iNOS, Il10, Il12b, Il23a, Irf5, and Hprt (Life Technologies) and gene expression was analysed using the change-in-threshold AACt-method.