The expression of other Th1/Th17-related soluble factors (IL22
, NFKB1, IL23A, STAT3, CCR5, IL17RA, CX3CL1, CXCL12, and CXCL5) was also assessed by RT-PCR, and the amount of mRNA calculated as above described.
Group 1 producing IFN gamma, Group 2 producing IL5 and IL13, Group 3 producing IL17 and/or IL22
. NH cells, nuocytes and lh2 cells are able to produce IL5 and IL13 in response to IL25 OR IL33.
Nakagawa et al., "Genetic polymorphisms in the IL22
gene are associated with psoriasis vulgaris in a Japanese population," Journal of Dermatological Science, vol.
In addition, interferon-gamma (IFN-[gamma]) has been shown to be elevated in lesion effluent , and suppression of IL22
 along with the IL12/23 pathways is thought to play a role in pathogenesis [20, 21].
As shown in Figure 3, the upregulation of IL-1[beta], IL-6, IL-8, IL-17A, IL22
, IL-23, and TNF-[alpha] expression was markedly decreased in the groups treated with acitretin and WCR.
(37) We could not find relevant information in field literature about IL22
gene polymorphisms and immunity against HBV, so comparing our results with other studies was not possible but there are several reports on IL-22 gene variants and other diseases.
significantly increased by PRM, CBZ, LEV, OXC, TPM, and lithium and decreased by VPA.
These findings suggest that IL22
has a protective role for the development of antigen-induced airway inflammation in mice during the effector phase.
IL19 and IL22
. Serum levels of these cytokines are decreased in women with ovarian endometrioma .
Nearby genes implicated as possibly playing a role in ulcerative colitis include the ring finger protein 186 (RNF186), OTU domain containing 3 (OTUD3), and phospholipase A2, group IIE (PLA2G2E) - genes on chromosome 1p36, and the interferon, gamma (IFNG), interleukin 26 (IL26), and interleukin 22 (IL22
) genes on chromosome 12q15 that play an important role in inflammation.
The activation of Th17 cells results in a large amount of inflammatory cytokine production, such as IL17A, IL17F, IL21, IL22
, and CCL20 [11, 32].