IL21

IL21

A gene on chromosome 4q26-q27 that encodes IL-21, a cytokine with immunoregulatory activity that may promote the transition between innate and adaptive immunity. IL21 induces the production of IgG1 and IgG3 in B cells, and may play a role in proliferation and maturation of natural killer cells in synergy with IL15. It is also a less preferred gene symbol for what is now designated as IL17C (see there), as well as IL22 (see there).
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Panels (a)-(l) represent TNF-[alpha], IL-1[beta], TGF-[beta], CD68, IL21, IL23, CD40, CD40 Ligand, IL-17a, CCL21, CCL19, and CXCL12.
SGECs of SS patients can present autoantigens and provide costimulatory signals such as CD40, CD80, and CD86 to activate T cells [32] and induce differentiation of naive [CD4.sup.+] T cells into Tfh expressing ICOS and IL21 through ICOSLG and IL6 [22].
Moreover, trastuzumab-induced IL21 expression in CD4+ T lymphocytes drives CD8+ T cell antitumor responses against HER2-positive tumors [33].
Indeed, the differentiation of Th17cells from [CD4.sup.+]-[CD161.sup.+] naive Th cells requires specific cytokines such as TGF-[beta], IL6, IL1[beta], IL21, and IL23 [13, 14].
IL21 binds to the corresponding receptor on the B cell surface to assist B cells in producing high-affinity antibodies.
With regard to polyphenol effects on Ob PBMCs, the most striking finding is represented by their inability to induce IL21 production.
Neutralizing IL21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis.
IL21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells.
MYST4 CD109, Inhibit the IL21, PLD2 expression of BCR-ABL miR-451 Associated with TSC1, ACADSB, [75] Bcr-Abl GRSF1, MAML1, GDI1, NAMPT miR-29b Inhibits ABL1 and HAS3, SNX24, BCR/ABL1 there by CD93, SCML2, [76] inhibiting cell COL7A1, ZNF396, growth and colony HMGCR, ICOS formation miR-138 Represses BCR/ABL1 KLF12, H3F3B, [77] and CCND3, MYO5C, NXN, NEBL, increases by GATA1 PDPN, STK38 miR-212 Increases the APAF1, EP300, [78] ABCG2 expression EDNRA, CFL2, NOS1, SOX4, SOX11
Cytokines in the [gamma]c family, such as IL-2, IL-7, IL-15, and IL21, have been shown to play a role in the maturation and function of T cells.
Gene B-cell Neutrophil NF[kappa]B function and and monocyte signaling signaling function and signaling ATG5 * BANK1 X * BLK X * CD44 ETS1 X * HLA-DR2 X * HLA-DR3 X * ICAMs X * IFIH1 IKZF1 X * IL10 X * X * IL21 X * IRF7 IRF8 X * X * ITGAM X * LYN X * NCF2 X * PHRF1 PRDM1 X * RASGRP3 X * SLC15A4 X * STAT4 TNFAIP3 X * TNFSF4 TNIP1 X * TYK2 UBE2L3 Total 13 4 3 Gene T-cell TLR and type function and I IFN signaling signaling ATG5 BANK1 BLK CD44 X * ETS1 X * HLA-DR2 X * HLA-DR3 X * ICAMs IFIH1 X * IKZF1 X * IL10 X * IL21 X * IRF7 IRF8 X * ITGAM LYN NCF2 PHRF1 X * PRDM1 X * X * RASGRP3 SLC15A4 STAT4 X * X * TNFAIP3 TNFSF4 X * TNIP1 TYK2 UBE2L3 Total 10 5
LIVE ASTROLOGY 1580 A il21 April 21 to May 21 Taurus THIS week you have to be brave and keep pushing forward.