IL2RA

(redirected from IL2-RA)

IL2RA

A gene on chromosome 10p15-p14 that encodes the alpha subunit of interleukin-2 (IL-2) receptor, which forms either a heterodimer with the beta subunit, resulting in a receptor with intermediate-affinity for IL-2, or a heterotrimer with beta and gamma subunits, resulting in a high-affinity IL-2 receptor.

Molecular pathology
Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10.
References in periodicals archive ?
Patient Age/race/ Donor Induction Time to 1st PCR number sex/weight type/PRA 1st PCR (copies) (kg) (%) (days) 1 28/AA/M/95 D/16 ATG 178 42807 2 39/W/M/105 L/0 IL2-ra 90 1857 3 32/AA/M/116 D/0 ATG 85 741 4 32/AA/M/82 D/88 ATG 104 2987 Patient SCr/GFR/CrCl Dose-adjusted Peak PCR number at time of for CrCl at (copies) 1st PCR time of 1st PCR (mg/day) 1 2.2/43/53 900 42807 2 1.7/45/74 450 2257 3 1.8/53/67 450 6240 4 1.5/65/73 450 2987 ATG: antithymocyte globulin; AA: African American; CrCl: creatinine clearance (mL/min); D: deceased donor; GFR: glomerular filtration rate (mL/min/[1.73.sup.2]); IL2-ra: interleukin 2 receptor antagonist; L: living donor; M: male; PCR: polymerase chain reaction; PRA: panel reactive antibodies; SCr: serum creatinine (mg/dL); W: White.