Se sugiere que el mecanismo consiste en la estimulacion sinergica de la Quimiocina CC Motivo ligando (CCL2) y el factor de crecimiento endotelial C (VEGFC), y la inhibicion de TIMP3 moderando la accion de MMP9 activada por IL1B
, induciendo de manera efectiva la invasion (Bourdiec et al., 2013).
is a cytokine which responds to inflammation and stimulates the expression of genes related to inflammation.
The inflammation processes involved during anterior cruciate ligament (ACL) injuries are accompanied by upregulation of interleukin-1[beta] (IL-1[beta], encoded by the IL1B
human gene) production.
TNF and IL1B
expression were not significantly increased.
The following genes were analyzed: interleukin-1 beta (IL1b
), interleukin-6 (IL6), nuclear factor erythroid 2-related factor 2 (NRF2), and superoxide dismutase 1 (SOD1).
Among differentially expressed genes, IL1B
, IL17F, IL6R, CXCL2, CCL20 and CCL25 were selected based on their immunological functions and CD8B and CD81 may contribute to variations of blood T lymphocyte subsets.
Association of IL1A, IL1B
, and TNF gene polymorphisms with chronic rhinosinusitis with and without nasal polyposis: a replication study.
For the first time, recent evidence demonstrated a significant reduction in adverse cardiovascular events targeting interleukin-1 beta (IL1B
), a cytokine that is central to the inflammatory response.
Ljunggren et al., "IL6 and IL1B
polymorphisms are associated with fat mass in older men: the MrOS Study Sweden," Obesity, vol.
Specifically, the IL1B
gene promoter single nucleotide polymorphism (SNP) C-511T (rs16944) has been shown to be associated with schizophrenia in European populations, though the data are not univocal [30-33] and to affect brain structure and functions in schizophrenic patients [34-36].
The remaining 88 patients with CPA were divided into the high and low IL1B
groups according to the median serum IL-1B concentration of 20.3 ng/L for further subgroup analysis (Table 1).