IL1B


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IL1B

A gene on chromosome 2q14 that encodes interleukin-1B, a cytokine produced by activated macrophages as a proprotein, which is proteolytically activated by caspase 1 (CASP1/ICE). IL-1B is a key mediator of inflammation and is involved in an array of cellular activities, including cell proliferation, differentiation and apoptosis.
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Se sugiere que el mecanismo consiste en la estimulacion sinergica de la Quimiocina CC Motivo ligando (CCL2) y el factor de crecimiento endotelial C (VEGFC), y la inhibicion de TIMP3 moderando la accion de MMP9 activada por IL1B, induciendo de manera efectiva la invasion (Bourdiec et al., 2013).
IL1B is a cytokine which responds to inflammation and stimulates the expression of genes related to inflammation.
The inflammation processes involved during anterior cruciate ligament (ACL) injuries are accompanied by upregulation of interleukin-1[beta] (IL-1[beta], encoded by the IL1B human gene) production.
TNF and IL1B expression were not significantly increased.
The following genes were analyzed: interleukin-1 beta (IL1b), interleukin-6 (IL6), nuclear factor erythroid 2-related factor 2 (NRF2), and superoxide dismutase 1 (SOD1).
Among differentially expressed genes, IL1B, IL17F, IL6R, CXCL2, CCL20 and CCL25 were selected based on their immunological functions and CD8B and CD81 may contribute to variations of blood T lymphocyte subsets.
For the first time, recent evidence demonstrated a significant reduction in adverse cardiovascular events targeting interleukin-1 beta (IL1B), a cytokine that is central to the inflammatory response.
Ljunggren et al., "IL6 and IL1B polymorphisms are associated with fat mass in older men: the MrOS Study Sweden," Obesity, vol.
Specifically, the IL1B gene promoter single nucleotide polymorphism (SNP) C-511T (rs16944) has been shown to be associated with schizophrenia in European populations, though the data are not univocal [30-33] and to affect brain structure and functions in schizophrenic patients [34-36].
The remaining 88 patients with CPA were divided into the high and low IL1B groups according to the median serum IL-1B concentration of 20.3 ng/L for further subgroup analysis (Table 1).