IL1A


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IL1A

A gene on chromosome 2q14 that encodes a protein belonging to the IL1 family of cytokines that is multifunctional and involved in various immune responses, inflammatory processes and haematopoiesis. It is produced by monocytes and macrophages as a proprotein, proteolytically processed, released in response to cell injury and induces apoptosis.

Molecular pathology
IL1 polymorphisms are associated with rheumatoid arthritis and Alzheimer's disease.
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Genes that are related to complex diseases, like cytochrome P450 (CYP3A) [35], asthma (IL-13 [36], IL4 [37,38] and IL1A [39]), cardiovascular disease (matrix metallopeptidase 3 [MMP3] [40] and angiotensinogen [ACT] gene [41] type 2 diabetes calpain-10 [CAPN10] [36]) have also been reported to have signatures of selection.
Association of IL1A, IL1B, and TNF gene polymorphisms with chronic rhinosinusitis with and without nasal polyposis: A replication study.
These genes encoded cytokines (CSF3, CSF2, CCL3, TNF, CCR1, IL13, KIT, CCL5, CCL4, IL10, CXCL10, IL12RB2, IFNG, IL1B, IL1A, IL8, MET, CD40, HGF, LEP, CXCL16, CX3CR1, CCR2, PDGFRA, IL12B, IL2), lipid metabolism related genes (CD36, GPX4, LPIN1, LPL, LPB), transcription regulators (BCL3, FOS and NFKBIA), receptors (TNF, IL8, RELA, TLR1, TIRAP, TLR2, NFKBIA, NFKB1, TLR4, CD40, CCL5, CXCL10, FOS, JUN, MAP3K8, IL1B, LBP, IL12B, CD14, SPP1), and others such as SELP, SELL, and SOD1, all play a role in some aspect of the immune response including cytokine activity (IL10, TNF, IL8, and IL1B), cell adhesion (SELL and SELP), immune activation (CD14 and TLR2), acute phase reaction (TNF, IL1B, and SAA3), apoptosis (BCL2, BAX).
In comparison, the finding of molecular targets in the MAPK pathway (MAPK3, IL1A, JUN, NFKB1, TGFB1, TNF, TP53, and FOS) is consistent with previous toxicity studies in Sertoli cells (Qi et al.
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation," Nature Cell Biology, vol.
Algunos marcadores geneticos se han descrito como heredables para aumento del riesgo de preeclampsia como: COL1A1, COL4A2 (por sus siglas en ingles colagen alfa 1 chain o 4 alfa 2), IL1A, PLAUR (urokinase plasminogen activator surface receptor), entre otros.
Por lo tanto, existen pocas evidencias sobre el papel que desempenan los polimorfismos presentes en el gen IL1A en el riesgo de muerte en pacientes con sepsis (18,41).
The IL1A (-889) gene polymorphism is associated with chronic periodontal disease in a sample of Brazilian individuals.
This review and meta-analysis show that IL1A and IL1B genetic variations are significant contributors to chronic periodontitis in Caucasians," said Dr.
000 factor, alpha-induced protein 6 6590338 IL1A (b) interleukin 1, 2.
Several polymorphisms within the IL1 gene cluster have been reported to influence the transcription of IL-1, including polymorphisms within the IL1A gene [(-889)C/T and (+4845)G/T], the IL1B gene [(-511)C/T, (-31)C/T, and (+3954)C/T], and the IL1RA gene [(+2018)C/T].
Cluster 1 genes (ZBTB1, PML, ZNF44, SIX1, BCL6, ZNF450) were down-regulated by V and involved in gene transcription, whereas cluster 2 genes (IL8, IL1A, PTGS2, DTR, TNFAIP3, CXCL3) were up-regulated and linked to inflammatory response and cell proliferation.