IL1A


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IL1A

A gene on chromosome 2q14 that encodes a protein belonging to the IL1 family of cytokines that is multifunctional and involved in various immune responses, inflammatory processes and haematopoiesis. It is produced by monocytes and macrophages as a proprotein, proteolytically processed, released in response to cell injury and induces apoptosis.

Molecular pathology
IL1 polymorphisms are associated with rheumatoid arthritis and Alzheimer's disease.
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In particular, IL1A and PTGS2 played central roles in the interaction network characterizing the gene expression signature associated with benzene in this study.
5-fold at all four doses relative to unexposed controls, including five genes [PTX3 (pentraxin-related gene), CD44 (CD44 antigen), PTGS2 (prostaglandin-endoperoxide synthase 2), IL1A (interleukin 1, alpha), and SERPINB2 (serpin peptidase inhibitor, clade B, member 2) with FDR-adjusted p-values [less than or equal to] 0.
000 factor, alpha-induced protein 6 6590338 IL1A (b) interleukin 1, 2.
The frequencies of the IL1A variants [(-889)C/T and (+4845)G/T] as well as the polymorphisms within the IL1B gene [(-511)C/T, (-31)C/T, and (+3954)C/T] did not differ significantly between the patient group and the control population (Table 1) or between survivors and nonsurvivors.
Controls All patients Genotype (n = 481) (n = 285) P (a) IL1A (-889), n (%) C/C 248 (51.
The IL1A (-889)C/T, IL1A (+4845)G/T, IL1B (-511)C/T, IL1B (-31)C/T, IL1B (+3954)C/T, and IL1RA (+2018)C/T single-nucleotide polymorphisms were genotyped by a multiplexed mutagenic separated-PCR assay.
The allele-specific PCR products [305 by for IL1A (-889)C, 317 by for IL1A (-889)T, 170 by for IL1A (+4845)T, 183 by for IL1A (+4845)G, 279 by for IL1B (-511)C, 289 by for IL1B (-511)T, 252 by for IL1B (-31)C, 262 by for IL1B (-31)T, 230 by for IL1B (+3954)C, 240 by for IL1B (+3954)T, 204 by for IL1RA (+2018)C, and 212 by for IL1RA (+2018)T] were separated on PolyNAT 12% S-50 Wide Mini Gels (Elchrom Scientific) by electrophoresis for 2.
Cluster 1 genes (ZBTB1, PML, ZNF44, SIX1, BCL6, ZNF450) were down-regulated by V and involved in gene transcription, whereas cluster 2 genes (IL8, IL1A, PTGS2, DTR, TNFAIP3, CXCL3) were up-regulated and linked to inflammatory response and cell proliferation.
Cluster 2 contained IL8, IL1A, PTGS2, DTR, TNFAIP3, and CXCL3 that were up-regulated and linked primarily to inflammatory response and cell proliferation.
The stimulatory effects of V on IL1A and TNFAIP3 gene expression, however, have not been reported.
Five genes (IL8, IL1A, CXCR4, RALBP1, and SCYE1) have been implicated in chemotaxis of the early inflammatory response, especially IL8, which is a critical mediator for neutrophil-dependent acute inflammation (Mukaida 2000, 2003).
This review and meta-analysis show that IL1A and IL1B genetic variations are significant contributors to chronic periodontitis in Caucasians," said Dr.