IL1A


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IL1A

A gene on chromosome 2q14 that encodes a protein belonging to the IL1 family of cytokines that is multifunctional and involved in various immune responses, inflammatory processes and haematopoiesis. It is produced by monocytes and macrophages as a proprotein, proteolytically processed, released in response to cell injury and induces apoptosis.

Molecular pathology
IL1 polymorphisms are associated with rheumatoid arthritis and Alzheimer's disease.
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References in periodicals archive ?
Contribution of single nucleotide polymorphisms of the IL1A gene to the cleavage of precursor IL-1alpha and its transcription activity.
In the present study, paracetamol hepatotoxicity was associated with an increase in serum level of IL1a. Similar results were reported by other investigators (51-52).
We evaluated the mRNA expression of the following proinflammatory cytokine [interleukin-1a (IL1A), interleukin-6 (IL6), interleukin-8 (IL8) and tumour necrosis factor (TNF)] and bone formation [alkaline phosphatase (ALP), collagen type 1 (COL1) and runt-related transcription factor 2 (RUNX2)] genes.
FcgRIIA (R131 or H131, rs1801274) (2009) (17) FCgRlllB (NA1 or NA2, rs1050501) IL1A (-889, rs1800587) IL1B (+3954, rs1143634) Morsani et al.
IL23R was upregulated in all tested patients one hour postephrin-B2 stimulation, and eight genes (IL1A, IL1B, CCL2, CDKN2B, TNFAIP6, HEY1, ITGB8, and GJB2) were upregulated in all patients four hours poststimulation.
(b) Low IL1A expression intensity in the normal bladder tissues adjacent to carcinoma with IHC was shown.
In IL1A (rs17561), a statistically significant difference in distribution of genotypes was found between PVR patients and healthy controls (OR, 3.00; 95% CI, 0.77 to 11.75; P = 0.036).
Brew, "The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia," HIV Medicine, vol.
have reported robust activation of microglia and elevated expression of IL1a, TNF[alpha], and IFN[gamma] in the striatum after striatal injection of monomeric [alpha]-synuclein.
Genes that are related to complex diseases, like cytochrome P450 (CYP3A) [35], asthma (IL-13 [36], IL4 [37,38] and IL1A [39]), cardiovascular disease (matrix metallopeptidase 3 [MMP3] [40] and angiotensinogen [ACT] gene [41] type 2 diabetes calpain-10 [CAPN10] [36]) have also been reported to have signatures of selection.
The IL1A genotype is associated with nasal polyposis in asthmatic adults.