Contribution of single nucleotide polymorphisms of the IL1A
gene to the cleavage of precursor IL-1alpha and its transcription activity.
In the present study, paracetamol hepatotoxicity was associated with an increase in serum level of IL1a
. Similar results were reported by other investigators (51-52).
Association of IL1A
, IL1B, and TNF gene polymorphisms with chronic rhinosinusitis with and without nasal polyposis: a replication study.
We evaluated the mRNA expression of the following proinflammatory cytokine [interleukin-1a (IL1A
), interleukin-6 (IL6), interleukin-8 (IL8) and tumour necrosis factor (TNF)] and bone formation [alkaline phosphatase (ALP), collagen type 1 (COL1) and runt-related transcription factor 2 (RUNX2)] genes.
FcgRIIA (R131 or H131, rs1801274) (2009) (17) FCgRlllB (NA1 or NA2, rs1050501) IL1A
(-889, rs1800587) IL1B (+3954, rs1143634) Morsani et al.
IL23R was upregulated in all tested patients one hour postephrin-B2 stimulation, and eight genes (IL1A
, IL1B, CCL2, CDKN2B, TNFAIP6, HEY1, ITGB8, and GJB2) were upregulated in all patients four hours poststimulation.
(b) Low IL1A
expression intensity in the normal bladder tissues adjacent to carcinoma with IHC was shown.
(rs17561), a statistically significant difference in distribution of genotypes was found between PVR patients and healthy controls (OR, 3.00; 95% CI, 0.77 to 11.75; P = 0.036).
Brew, "The relationship between ApoE, TNFA, IL1a
, IL1b and IL12b genes and HIV-1-associated dementia," HIV Medicine, vol.
have reported robust activation of microglia and elevated expression of IL1a
, TNF[alpha], and IFN[gamma] in the striatum after striatal injection of monomeric [alpha]-synuclein.
Genes that are related to complex diseases, like cytochrome P450 (CYP3A) , asthma (IL-13 , IL4 [37,38] and IL1A
), cardiovascular disease (matrix metallopeptidase 3 [MMP3]  and angiotensinogen [ACT] gene  type 2 diabetes calpain-10 [CAPN10] ) have also been reported to have signatures of selection.
genotype is associated with nasal polyposis in asthmatic adults.