IL18


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IL18

A gene on chromosome 11q22.2-q22.3 that encodes IL-18, a proinflammatory cytokine that increases natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
References in periodicals archive ?
We found a significant association between IL18 -137G/C genetic polymorphism with the risk of CAD only in hypertensive and smoker subgroups of patients.
CXorf26, IL18, PTGES3, CALM3, TCEB2, MYL6, RPP2, BANF1 and RPL23were most differentially expressed in HaCaT proteome following DNBS stimulation.
Predesigned TaqMan primers and probes for IL1B (Hs01555410_m1), TNF (Hs00174128_m1), IL18 (Hs01038788_m1), SERPINE1 (Hs01126606_m1), CD40 (Hs01002913_g1), CCL2 (Hs00234140_m1), and TLR4 (Hs00152939_m1) genes were used (Applied Biosystems).
Excessive inflammasome activation can promote excessive release of IL-1[beta] and IL18, causing autoinflammatory disorders and the subsequent development of autoimmune diseases, such as SLE [42].
Real-time quantitative PCR (RT-qPCR) was performed to investigate the expression levels of genes involved in the NLRP3 inflammatory pathway, including IL-1[beta], IL18, and NLRP3.
The combined factor of etiological candidate genes (CTLA4, IL18, TLR9, CARD4, TGF[beta]1, etc.) and environment (food, sweating, stress, temperature, etc.) is the main etiology of atopic dermatitis [4, 5].
A further evidence for immune activation is that interleukins IL1B, IL6, IL8, and IL18 and the Toll-like receptors TLR2 and TLR4 also tended to be upregulated in the obese animals.
Previous studies demonstrated that IL18 upregulates the expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the endothelial cells that play important role in inflammation process [8].
The first group of genes consisted of cytokine genes and genes related to cytokine signaling: TNF [5] [tumor necrosis factor (TNF superfamily, member 2)], IL1B (interleukin 1, beta), IL10 (interleukin 10), IL18 [interleukin 18 (interferon-gamma-inducing factor)], SOCS3 (suppressor of cytokine signaling 3), TGFB1 (transforming growth factor, beta 1), and IL6 [interleukin 6 (interferon, beta 2)].
Ceperuelo-Mallafre et al., "Leptin and adiponectin, but not IL18, are related with insulin resistance in treated HIV-1-infected patients with lipodystrophy," Cytokine, vol.
The genetic variants of pro-inflammatory cytokines (IL4, IL13, IL10, IL18, TNF, and IFNGR1), the cytokine receptor (IL4R), the genes involved in the IgE/Fc[epsilon]RI pathway (the galectin-3 gene (LGALS3)), and nucleotide-binding oligomerization domain (NOD) gene polymorphisms are also strongly associated with betalactam-induced immediate reactions (Table 2) [67-73].