We found a significant association between IL18
-137G/C genetic polymorphism with the risk of CAD only in hypertensive and smoker subgroups of patients.
, PTGES3, CALM3, TCEB2, MYL6, RPP2, BANF1 and RPL23were most differentially expressed in HaCaT proteome following DNBS stimulation.
Predesigned TaqMan primers and probes for IL1B (Hs01555410_m1), TNF (Hs00174128_m1), IL18
(Hs01038788_m1), SERPINE1 (Hs01126606_m1), CD40 (Hs01002913_g1), CCL2 (Hs00234140_m1), and TLR4 (Hs00152939_m1) genes were used (Applied Biosystems).
Excessive inflammasome activation can promote excessive release of IL-1[beta] and IL18
, causing autoinflammatory disorders and the subsequent development of autoimmune diseases, such as SLE .
Real-time quantitative PCR (RT-qPCR) was performed to investigate the expression levels of genes involved in the NLRP3 inflammatory pathway, including IL-1[beta], IL18
, and NLRP3.
The combined factor of etiological candidate genes (CTLA4, IL18
, TLR9, CARD4, TGF[beta]1, etc.) and environment (food, sweating, stress, temperature, etc.) is the main etiology of atopic dermatitis [4, 5].
A further evidence for immune activation is that interleukins IL1B, IL6, IL8, and IL18
and the Toll-like receptors TLR2 and TLR4 also tended to be upregulated in the obese animals.
Previous studies demonstrated that IL18
upregulates the expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the endothelial cells that play important role in inflammation process .
The first group of genes consisted of cytokine genes and genes related to cytokine signaling: TNF  [tumor necrosis factor (TNF superfamily, member 2)], IL1B (interleukin 1, beta), IL10 (interleukin 10), IL18
[interleukin 18 (interferon-gamma-inducing factor)], SOCS3 (suppressor of cytokine signaling 3), TGFB1 (transforming growth factor, beta 1), and IL6 [interleukin 6 (interferon, beta 2)].
Ceperuelo-Mallafre et al., "Leptin and adiponectin, but not IL18
, are related with insulin resistance in treated HIV-1-infected patients with lipodystrophy," Cytokine, vol.
The genetic variants of pro-inflammatory cytokines (IL4, IL13, IL10, IL18
, TNF, and IFNGR1), the cytokine receptor (IL4R), the genes involved in the IgE/Fc[epsilon]RI pathway (the galectin-3 gene (LGALS3)), and nucleotide-binding oligomerization domain (NOD) gene polymorphisms are also strongly associated with betalactam-induced immediate reactions (Table 2) [67-73].