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For example, the IL17A and IL17F gene polymorphisms were not associated with the susceptibility of RA, while they were among the most important cytokines in the pathogenesis of RA.
IL17A and IL17F gene polymorphisms in patients with rheumatoid arthritis.
The association of IL17 A G197A polymorphism (rs2275913) and IL17F A7488G polymorphism (rs763780) in the gene of these cytokines have been reported with diseases such as rheumatoid arthritis, colon inflammatory disease, lung cancer and gastric cancer [16-18].
In this study, the gene polymorphisms at position G197A (rs2275913) in IL17A gene and A7488G (rs763780) in IL17F gene were studied among 192 patients with breast cancer and 215 women as controls.
In the present study the gene polymorphisms in IL17 A G197A (rs2275913) and IL17F (A7488G (rs763780) were investigated in patients with breast cancer compared with the healthy control group.
In contrast, such a difference was not observed in the case of IL17F A7488G polymorphism (rs 763780) .
Estas celulas se caracterizan por la produccion de citocinas como IL17A, IL17F, IL-21, IL-22, IL-26 y CCL20 (en humanos).
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- IL12, subunit p40
- IL1RA, CD121 antigen-like family member A