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Among differentially expressed genes, IL1B, IL17F, IL6R, CXCL2, CCL20 and CCL25 were selected based on their immunological functions and CD8B and CD81 may contribute to variations of blood T lymphocyte subsets.
Th1 cells secrete more interferon [gamma], while Th17 cells regulate tissue inflammation by producing IL-17A and IL17F .
For example, the IL17A and IL17F gene polymorphisms were not associated with the susceptibility of RA, while they were among the most important cytokines in the pathogenesis of RA.
Genotype frequencies of all SNPs tested in control subjects were consistent with those expected from the Hardy-Weinberg equilibrium (HWE) except for rs1884444 polymorphism in the IL23R gene and rs763780 in IL17F gene (P < 0.001).
Previous studies show that genetic polymorphisms of IL17A G197A and IL17F T7488C affect the production of IL-17A and F, respectively [12, 13].
In this IL-17 signaling pathway, homozygous IL17RA, IL17RC, ACT 1, and heterozygous IL17F mutations were found to be causative in some CMCD patients [1, 2, 9].
Unfortunately, although there are improved methods to reduce the protein-protein interaction's false positive rate [31, 32], the information of protein-protein interactions is always incomplete so that there are some isolated nodes (e.g., PDXP, ODZ1, NT5M, and IL17F) and small components that only contained two or three nodes (e.g., the component consisting of KLRG1 and LEPROTL1 and the component consisting of PCYT2 and JMJD5).
The association of IL17 A G197A polymorphism (rs2275913) and IL17F A7488G polymorphism (rs763780) in the gene of these cytokines have been reported with diseases such as rheumatoid arthritis, colon inflammatory disease, lung cancer and gastric cancer [16-18].
investigated possible associations between genetic polymorphisms of IL17A G197A and those of IL17F T7488C with Chagas Disease (CD) and/or the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas cardiomyopathy (CCC).
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- IL12, subunit p40
- IL1RA, CD121 antigen-like family member A