IL17A

IL17A

A gene on chromosome 6p12 that encodes interleukin-17A, a proinflammatory cytokine produced by activated T cells which regulates NF-kappaB and mitogen-activated protein kinases. It upregulates IL6 and cyclooxygenase-2 and increases nitric oxide production.

Molecular pathology
IL17A is overexpressed in rheumatoid arthritis, psoriasis and multiple sclerosis.
References in periodicals archive ?
For example, the IL17A and IL17F gene polymorphisms were not associated with the susceptibility of RA, while they were among the most important cytokines in the pathogenesis of RA.
IL17A and IL17F gene polymorphisms in patients with rheumatoid arthritis.
Cosentyx is a targeted biologic therapy that selectively binds to IL17A which stops it from binding to its receptors and causing inflammation.
Thus, their results showed that IL17A polymorphisms may influence the risk for HCC in chronic HBV infection through IL17A production.
IL17A gene polymorphisms, serum IL-17A and IgE levels, and hepatocellular carcinoma risk in patients with chronic hepatitis B virus infection.
ELISA showed that rWISP1 enhanced the production of IL17A in LPMCs from healthy controls, CD patients, and UC patients (Figure 3(d)).
Indeed, in AMAGINE-3, the 12week Psoriasis Area Severity Index (PASI) 75 rate among patients on brodalumab at 210 mg every 2 weeks --the more effective dose of the IL17A inhibitor--was 85.
The amplified IL17A and IL17 F fragments underwent restriction endonuclease reactions at 37 [degrees] C for 16 hours with XagI (Fermentas, Canada)and Nlalll (Fermentas, Canada) restriction enzymes respectively.
In this study, the gene polymorphisms at position G197A (rs2275913) in IL17A gene and A7488G (rs763780) in IL17F gene were studied among 192 patients with breast cancer and 215 women as controls.
Table 3 illustrates the frequencies of genotypes and alleles at G197A position in IL17A gene as well as A7488G locus in IL17 F gene.
Estas celulas se caracterizan por la produccion de citocinas como IL17A, IL17F, IL-21, IL-22, IL-26 y CCL20 (en humanos).
Neutralization of IL-17A in EAE in wild-type mice with a monoclonal antibody (Figure 3) as well as with an Fc-Receptor fusion protein (which neutralizes both IL17A and IL-17F) showed therapeutic efficacy, (50) but no complete reduction of disease symptoms.