IL17A

IL17A

A gene on chromosome 6p12 that encodes interleukin-17A, a proinflammatory cytokine produced by activated T cells which regulates NF-kappaB and mitogen-activated protein kinases. It upregulates IL6 and cyclooxygenase-2 and increases nitric oxide production.

Molecular pathology
IL17A is overexpressed in rheumatoid arthritis, psoriasis and multiple sclerosis.
References in periodicals archive ?
The cytokines detected were IFNI3, IL-10, IL-12p70, IL-13, IL-2, IL-5, IP-10, MiP-1[alpha], MiP-1[beta], IL-6, IL1-RA, GM-CSF, RANTES, IL-1[beta], Eotaxin, Basic FGF, VEGF, PDGF-[beta], MCP-1, IL-8, IL15, IL-17, G-CSF, IL-12p70, IL17A, IL-9 and TNF-[alpha].
Raised levels of IFN-gamma and IL-13 are associated with pre-diabetes amongst newly diagnosed patients with Tuberculosis
(2016) MCPIP1 RNase is aberrantly distributed in psoriatic epidermis and rapidly induced by IL17A. J.
Post-transcriptional regulation of immune responses by RNA binding proteins
For example, the IL17A and IL17F gene polymorphisms were not associated with the susceptibility of RA, while they were among the most important cytokines in the pathogenesis of RA.[23]
IL1F7 Gene Polymorphism Is not Associated with Rheumatoid Arthritis Susceptibility in the Northern Chinese Han Population: A Case-Control Study
Supplementation with Microalgae Fatty Acids Increases IL17A, IL-12, IL-4, IL-6, IL-10, and TGF-[beta] but Decreases IFN-[gamma], TNF-[alpha], and IL-5 in Diabetic Mice.
Effect of Supplementation with n-3 Fatty Acids Extracted from Microalgae on Inflammation Biomarkers from Two Different Strains of Mice
However, data on whether IL17A is associated with severe S.
Low IL-6, IL-10, and TNF-[alpha] and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in Schistosoma mansoni Chronically Exposed Individuals
showed that IL17A upregulated COX-2 mRNA and protein in cancer cells lines via NF-[kappa]B and ERK1/2 signalling pathways [15].
[beta]-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC
Relative mRNA levels of IL17A, IL-23, Treg-related transcription factor FoxP3, and cytokine TGF-3 were measured by using quantitative PCR assay via the primers from Table 1.
Bifidobacterium lactis Ameliorates the Risk of Food Allergy in Chinese Children by Affecting Relative Percentage of Treg and Th17 Cells
Selected cytokines related to acute and chronic inflammation, IL6, IL12, IFN-[gamma], TNF-[alpha], IL2, IL4, IL5, IL13, IL10, TGF-[beta]11, IL17A, and G-CSF, were investigated by RT-PCR (as above reported) and by ELISA (Multi-Analyte ELISArray kit, Qiagen, Milan, Italy) as previously described [39].
Chronic Inflammation May Enhance Leiomyoma Development by the Involvement of Progenitor Cells
Serum levels of IL-17A were evaluated using an ELISA kit ("Thermo Fisher Scientific Human IL17A ELISA Kit") designed to measure human IL-17A in serum.
Association of Optic Neuritis with CYP4F2 Gene Single Nucleotide Polymorphism and IL-17A Concentration
In fact, the synergic action of the different cytokines induces the expression of IL23R, which in turn activates the STAT signaling pathway leading to the expression of the transcription factor ROR[gamma]t and then the production of Th17-specific cytokines, mainly IL17A and IL17F [15, 16].
Involvement of the IL23/Th17 Pathway in the Pathogenesis of Tunisian Pemphigus Foliaceus
Talor et al., "Fatal eosinophilic myocarditis develops in the absence of IFN-[gamma] and IL17A," The Journal of Immunology, vol.
Roles of Host Immunity in Viral Myocarditis and Dilated Cardiomyopathy
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