IL17A

IL17A

A gene on chromosome 6p12 that encodes interleukin-17A, a proinflammatory cytokine produced by activated T cells which regulates NF-kappaB and mitogen-activated protein kinases. It upregulates IL6 and cyclooxygenase-2 and increases nitric oxide production.

Molecular pathology
IL17A is overexpressed in rheumatoid arthritis, psoriasis and multiple sclerosis.
References in periodicals archive ?
The amplified IL17A and IL17 F fragments underwent restriction endonuclease reactions at 37 [degrees] C for 16 hours with XagI (Fermentas, Canada)and Nlalll (Fermentas, Canada) restriction enzymes respectively.
In this study, the gene polymorphisms at position G197A (rs2275913) in IL17A gene and A7488G (rs763780) in IL17F gene were studied among 192 patients with breast cancer and 215 women as controls.
Table 3 illustrates the frequencies of genotypes and alleles at G197A position in IL17A gene as well as A7488G locus in IL17 F gene.
The results indicated that the frequencies of investigated genotype and alleles in IL17A and IL17F genes are not significantly different in breast cancer and the control group.
in a reporter gene assay showed that the presence A allele at position 197 in IL17A gene induces more Losifraz activity than the G allele at this position.
The minor allele frequency (MAF) of IL17A A197G and IL17F A7488G polymorphisms in our population was 0.
Neutralization of IL-17A in EAE in wild-type mice with a monoclonal antibody (Figure 3) as well as with an Fc-Receptor fusion protein (which neutralizes both IL17A and IL-17F) showed therapeutic efficacy, (50) but no complete reduction of disease symptoms.
Increased numbers of the immune cells that produce IL17A, known as type3 innate lymphoid cells (ILC3 cells)
When the obese mice were genetically altered in that they could not produce IL17A or NLRP3, they did not develop asthma.