IL16


Also found in: Dictionary, Encyclopedia.

IL16

A gene on chromosome 15q26.3 that encodes interleukin-16, a pleiotropic cytokine that acts as a chemoattractant, a modulator of T-cell activation, and an inhibitor of HIV replication. IL-16 stimulates a migratory response in CD4+ T cells, monocytes and eosinophils; primes CD4+ T-cells for IL-2 and IL-15 responsiveness; and induces T-cell expression of IL-2 receptor.
References in periodicals archive ?
Seven genes (IL16, CCL1, EEF1G, CD84, MCL1, NFATC4 and IER-5) did not reveal any significant difference between Tharparkar and Vrindavani.
No significant difference in IL16, CCL1, EEF1G, CD84, MCL1, NFATC4 and IER-5 gene expression between Tharparkar and Vrindavani.
Caption: Fig 1a amplification of selected genes at annealing temperatures 58[degrees]C Lane 1: TLR2 (107 bp); Lane 2: NFKB1 (135 bp); Lane 3: IER5 (125 bp); Lane 4: PRKCB1 (141 bp); Lane 5: EEF-1 (222 bp); Lane 6: IL16 (51 bp); Lane 7: IL2 (183) bp; Lane 8: TNF (08 bp); Lane 9: EEF1-G (222 bp) M: 100 bp ladder
In the present study, IL16 polymorphisms, rs11556218 and rs4778889 were associated with LOAD in an Iranian population.
According to Genecards database, IL16 gene is correlated with 84 different disorders containing LOAD.