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The cytokines detected were IFNI3, IL-10, IL-12p70, IL-13, IL-2, IL-5, IP-10, MiP-1[alpha], MiP-1[beta], IL-6, IL1-RA, GM-CSF, RANTES, IL-1[beta], Eotaxin, Basic FGF, VEGF, PDGF-[beta], MCP-1, IL-8, IL15, IL-17, G-CSF, IL-12p70, IL17A, IL-9 and TNF-[alpha].
CAR-T cells are engineered to find and destroy tumor cells and can be armed with powerful cytokines, such as IL12 and IL15, to further enhance anti-tumor immunity.
In human subjects, negative correlations between circulating IL-15 levels and both total and abdominal fat have been demonstrated.14 Nielson et al observed a negative correlation of plasma IL-15 levels and total fat mass (p <.001), BMI (p <.001) and trunk fat mass (p <.01).15 Animal experiments with knockout mice having deletion of IL15 (IL-15 KO mice) demonstrated greater quantity of body fat than controls.
Promising genetic candidates include genes involved in antiretroviral drugs pharmacodynamic pathways (12,13) and genes involved in immune functions (inflammation, apoptosis) and homeostasis, such as the interleukins IL2, IL7 and IL15, which coordinate T cell proliferation.
XmAb24306 is the first of a suite of tumor microenvironment activators using the IL15 bispecific platform.
Simpson et al., "A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavitary pulmonary aspergillosis," Clinical Microbiology and Infection, vol.
McElmurry et al., "IL15 trispecific killer engagers (TriKE) make natural killer cells specific to CD33+ targets while also inducing persistence, in vivo expansion, and enhanced function," Clinical Cancer Research, vol.
Interleukins [interleukin 8 (IL8), interleukin 6 signal transducer (IL6ST), interleukin 7 (IL7), interleukin 15 (IL15), and interleukin 1 receptor type 1 (IL1R1)] and chemokines [C-X-C motif chemokine ligand 2 (CXCL2), C-X-C motif chemokine ligand 6 (CXCL6), C-X-C motif chemokine ligand 10 (CXCL10), C-X-C motif chemokine ligand 11 (CXCL11), C-C motif chemokine ligand 5 (CCL5), and C-C motif chemokine ligand 28 (CCL28)] also were overexpressed in HT-29 cells.
Scdek et al., "Association of germline genetic variants in RFC, IL15 and VDR genes with minimal residual disease in pediatric B-cell precursor ALL," Scientific Reports, vol.
Many researches in the past decades have revealed that cytokines such as tumor necrosis alpha (TNF-a) and interleukins 1, 6, and 15 (IL1, IL6, and IL15), as well as immune-mediated inflammatory signaling pathways such as JAK-STAT, NF-[kappa]B, and MAPK signaling pathway, are deeply involved in the occurrence and development of RA [15].
It leads to over expression of IL15 along with upregulation of MICA and NKG2D over expression in intra epithelial lymphocytes.
factor (CLMF), secreted by activated B cells, macrophages, and other antigen presenting cells (APCs) but its production is inhibited by IL-4 and IL-10 IL15 (1) Originally produced by discovered activated as a T cell monocyte, stimulatory epithelial cells, activity and fibroblasts IL Genes mapped to chromosome Structure IL2 Long arm of 15 kDa chromosome 4.