IL12A

A gene on chromosome 3p12-q13.2 that encodes interleukin-12A, a cytokine which acts on T and natural killer cells and has a broad array of biological activities; it is required for the T-cell-independent induction of interferon-gamma, and is important for Th1 and Th2 cell differentiation. IL12A acts as a growth factor for activated T and NK cells and enhances the lytic activity of NK/lymphokine-activated killer cells.

Mentioned in ?

natural killer cell stimulatory factor 1

References in periodicals archive ?

Additionally IL12A, IL13, IL16 genes play an important role on the survival of NSCLC patients (30, 31).

New Insight of Tumor Microenvironment in Non-Small Cell Lung Cancer

As CD80 and CD86 are expressed by activated macrophages, we used qRT-PCR to check the expression of IL12A and IL12B genes encoding for the M1 cytokine IL12.

Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types

Meanwhile, we found that coculture upregulated the mRNA levels of IL12A and IL17A, markers for activated APCs and Th17, respectively, in PBMCs (Figure 3(a)) and mRNA levels of CD40, CD80, CD86, ICOSLG, and IFNy in SGECs (Figure 3(b)).

Inhibitory Effects of iPSC-MSCs and Their Extracellular Vesicles on the Onset of Sialadenitis in a Mouse Model of Sjogren's Syndrome

Association of IL12A Expression Quantitative Trait Loci (eQTL) With primary biliary cirrhosis in a Chinese Han population.

Variants in the Promoter Region of HLA-DQA1 were Associated with Idiopathic Membranous Nephropathy in a Chinese Han Population

Current N[O.sub.2] and [PM.sub.10] exposures at 16 y of age were linked to differential expression of IL1 b, IL12A, as well as IL13.

Exposure to traffic-related air pollution and serum inflammatory cytokines in children

Using the data from macrophages and fibroblasts, PathGen linked IL-27 to regulation of IL1[beta], TNF, and IL-6 through the IL12a and NF-[kappa]B/Rel pathways and to TRAF2 potentially through MDFI.

Combination of Interleukin-27 and MicroRNA for Enhancing Expression of Anti-Inflammatory and Proosteogenic Genes

Van Hagen et al., "Genome-wide association study in an admixed case series reveals IL12A as a new candidate in Behcet Disease," PLoS ONE, vol.

Knitting the Threads of Silk through Time: Behcet's Disease--Past, Present, and Future

Among these, IL12A, IL12RB2, IRF5, TNPO3, DENND1B, SPIB, TNFAIP2, CXCR5, CLEC16A, RAD51L1, IRF8, RPS6KA4, MAP3K7IP1, TNFRSF1A, PLCL2, ELMO1, and ARF7 played an important role in the morbidity of PBC in European ancestries, while TNFSF15 and POU2AF1 were unique in Japanese ancestries, and CD80, IKZK3, Il7R, NFKB1, and STAT4 were proved to be associated with PBC in both races.

The association between bile salt export pump single-nucleotide polymorphisms and primary biliary cirrhosis susceptibility and ursodeoxycholic acid response

Changes in IL12A methylation pattern in livers from mice fed DDC.

Epigenetic events in liver cancer resulting from alcoholic liver disease

A third SNP (rs17810546) located in the interleukin 12A gene (IL12A) was significantly associated with enthesitis-related arthritis.

Genetic variants confer susceptibility to JIA, type 1 diabetes, and celiac disease

IL-12 is a heterodimer comprised of two subunits: a 35kDa (p35) light chain encoded by IL12A gene and a 40kDa heavy chain (p40), encoded by IL12B gene.

Polymorphisms of IL12RB2 May Affect the Natural History of Primary Biliary Cholangitis: A Single Centre Study

However, these studies often uncovered different loci in the same signaling pathways across ethnicities; [8-12] genetic variants of the IL12 [alpha]-chain (IL12A) and IL12RB2 genes were associated with disease susceptibility in Caucasian studies, [8-11] but such associations have not been confirmed in the Japanese [12].

STAT4 gene polymorphisms are associated with susceptibility and ANA status in primary biliary cirrhosis