IL12A

IL12A

A gene on chromosome 3p12-q13.2 that encodes interleukin-12A, a cytokine which acts on T and natural killer cells and has a broad array of biological activities; it is required for the T-cell-independent induction of interferon-gamma, and is important for Th1 and Th2 cell differentiation. IL12A acts as a growth factor for activated T and NK cells and enhances the lytic activity of NK/lymphokine-activated killer cells.
References in periodicals archive ?
Association of IL12A Expression Quantitative Trait Loci (eQTL) With primary biliary cirrhosis in a Chinese Han population.
10] exposures at 16 y of age were linked to differential expression of IL1 b, IL12A, as well as IL13.
Changes in IL12A methylation pattern in livers from mice fed DDC.
S1_at IL12A Interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) Bt.
The IL12A gene has already been associated with celiac disease.
b)IL-12p70 was omitted as its levels are regulated by two genes, IL12A and IL12B.