IL10


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Related to IL10: IL13, IL2, TNF alpha

IL10

A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway.

Molecular pathology
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
References in periodicals archive ?
In the current study, there were increased IL6 and reduction of IL10 in small intestinal mucosal tissues of iron overloaded rats indicating increased intestinal mucosal inflammatory response; these findings are consistent with Yi-chen et al.
The best fit straight line was drawn and the concentrations of IL10 and IFN-[gamma] in test samples were obtained and recorded in pg/ml.
Recent reports showed that culturing macrophages on fibrin gels, fabricated by combining fibrinogen with thrombin-stimulated secretion of the anti-inflammatory cytokines, such as interleukin 10 (IL10).
Spiroski, "IL10 -1082, IL10 -819 and IL10 -592 polymorphisms are associated with chronic periodontitis in a Macedonian population," Human Immunology, vol.
Other noted immune abnormalities are heightened TH1 and TH2 activity, abnormal eosinophil response, and reduced production of IL10. Some of the CSS patients have hypergammaglobulinaemia and positive rheumatoid factor as well, which indicate the role of humoral immunity in the disease process.
No difference between diabetic and healthy subjects in the production of TNF[alpha] and IL10 upon LPS treatment have been found [36, 40], while in study by Geerlings et al.
These studies revealed numerous inflammatory molecules to be implicated in the PVR development, such as growth factors (PDGF, HGF, VEGF, and EGF), transforming growth factors (TGFA, TGFB), molecules from the SMAD family and interleukins (IL1, IL6, IL8, and IL10), tumor necrosis factors (TNF), and tumor suppressor protein (p53) [10-15].
A severe form of childhood-onset IBD results from polymorphisms in the IL10 gene or that of the Il10 receptor [71-74], which is a similar pathogenesis to the [IL10.sup.-/-] mouse.
Genotyping analysis of DRBI loci and cytokine genes was performed at the Department of Medical Biology Istanbul University Cytokine genotypes were determined by the polymerase chain reaction (PCR)-SSP method using a commercial kit (One Lambda, Inc., Canoga Park, CA, USA) that contains sequence-specific primers for determining the following polymorphisms: TNF-a (-308 G/A), TGF-[beta]1 (C/T codon 10, C/G codon 25), IL10 (-1082 G/A, -819 T/C, -592 A/C), IL-6 (-174 G/C), and IFN-[delta] (+874 A/T).
In addition, different studies have shown an association between other genes and loci including HLA-A26, KIAA1529, CPVL, LOC100129342, UBASH3B, UBAC2, IL10, IL23R-IL12RB2, and TNF and BS risk (48-50).
En ratones SAMR1 no hubo diferencias estadisticamente significativas en la expresion de TNF[alfa], IL-1[beta] y IL10 entre los ratones adultos y jovenes.
Variants in LTA, TNF IL1B and IL10 genes associated with the clinical course of sepsis.