IL1B

(redirected from IL1-BETA)

IL1B

A gene on chromosome 2q14 that encodes interleukin-1B, a cytokine produced by activated macrophages as a proprotein, which is proteolytically activated by caspase 1 (CASP1/ICE). IL-1B is a key mediator of inflammation and is involved in an array of cellular activities, including cell proliferation, differentiation and apoptosis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
It is already known that obesity and diabetes lead to an excessive, pathological activation of the immune system in which the messenger substance IL1-beta plays a central role.
Ayrica CTLA4-lg (Abatacept) monoterapisi faz II, anti IL1-beta antagonisti (Canakinumab) faz II, anti IL1-alfa antagonisti (Anakinra) faz II/III calisma olarak devam etmektedir (15).
Among the cytokines, often found to be over expressed at tumour level, IL1-beta, TNF-alpha, IL-6, IL-10, IFN-gamma, CX3CL1, to name just a few, have been closely related to pain for a long time [14-16].