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Related to IL-8: Il-6, TNF alpha


A gene on chromosome 4q13-q21 that encodes interleukin-8, a cytokine belonging to the CXC chemokine family. IL8 is a major mediator of inflammation, acting as a chemoattractant for neutrophils, basophils and T-cells, and is a potent angiogenic factor.

Molecular pathology
IL8 is a candidate gene for bronchiolitis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.




A type of cytokine that enables communication among leukocytes and other cells active in inflammation or the specific immune response. The result is a maximized response to a microorganism or other foreign antigen. See: cell-mediated immunity; cytokine; inflammation


Abbreviation: IL-1
A cytokine released by almost all nucleated cells that activates the growth and function of neutrophils, lymphocytes, and macrophages; promotes the release of additional mediators that influence immune responses; enhances production of cerebrospinal fluid; and modulates certain adrenal, hepatic, bone, and vascular smooth muscle cell activity. Interleukin-1 and tumor necrosis factors, whose actions are almost identical to those of IL-1, are involved in fever production and other systemic effects of inflammation. See: tumor necrosis factor


Abbreviation: IL-1-ß
A protein released by activated macrophages that stimulates B cells and thymocytes to proliferate and mature and increases the secretion of interleukin 2. It is found in high levels in the blood of patients with septic shock and in the cerebrospinal fluid of patients with meningitis.
Synonym: catabolin


Abbreviation: IL-2
A cytokine released primarily by activated CD4+ helper T lymphocytes. It is a major mediator of T cell proliferation, promotes production of other cytokines, enhances natural killer cell function, and is a cofactor for immunoglobulin secretion. Synonym: T-cell growth factor


Abbreviation: IL-3
A cytokine produced by activated T cells that promotes proliferation of bone marrow stem cells.
Synonym: mast cell growth factor; multi-colony stimulating factor


Abbreviation: IL-4
A cytokine released by activated T cells and mast cells that stimulates B and T lymphocyte production and activity, prevents macrophages from releasing monokines, and promotes mast cell, immunoglobulin E, and eosinophil activity.
Synonym: B cell growth factor; mast cell growth factor II; T-cell growth factor II


Abbreviation: IL-5
A cytokine produced by T cells, eosinophils and mast cells that acts as the primary stimulant for eosinophil production. Synonym: eosinophil colony-stimulating factor; eosinophil differentiation factor See: basophil(e); eosinophil


Abbreviation: IL-6
A lymphokine produced by many cell types, including mononuclear phagocytes, T cells, and endothelial cells. It mediates the acute phase response, enhances B cell production and differentiation to immunoglobulin-secreting plasma cells, and stimulates megakaryocyte production. Synonym: B cell stimulatory factor II; hepatocyte stimulatory factor See: acute phase reaction; lymphokine


Abbreviation: IL-7
A cytokine produced by the thymus, spleen, and bone marrow stromal cells. It stimulates growth of B-cell precursors, development of thymocytes, and activity of cytotoxic T-cells.
Synonym: lymphopoietin 1; pre-B cell growth factor


Abbreviation: IL-8
A cytokine produced by many cell types. It acts as a neutrophil chemoattractant.


Abbreviation: IL-9
A cytokine produced by T cells. Among other functions, it promotes the proliferation and multiplication of mast cells.


Abbreviation: IL-10
A cytokine derived from mononuclear phagocytes, T cells, and keratinocytes. It inhibits cytokine synthesis by macrophages, T cells, and natural killer cells, and enhances B cell growth and secretion of immunoglobulin.


Abbreviation: IL-11
A cytokine produced by bone marrow stromal cells. It mediates acute phase protein synthesis, enhances B cell growth and differentiation to plasma cells, and promotes megakaryocyte production.
Synonym: plasmocytoma stimulating factor


Abbreviation: IL-12
A cytokine produced by mononuclear phagocytes and B cells. It induces interferon gamma production from T cells and natural killer cells, and enhances T cell and natural killer cell cytotoxicity.
Synonym: natural killer cell stimulating factor


Abbreviation: IL-13
A cytokine produced by T cells. It induces major histocompatibility class II expression on mononuclear phagocytes and B cells, B cell proliferation, and immunoglobulin production.


Abbreviation: IL-14
A cytokine produced by T lymphocytes and follicular dendritic cells. It stimulates proliferation of activated B lymphocytes and inhibits immunoglobulin secretion from activated B lymphocytes.


Abbreviation: IL-15
A cytokine released by epithelial cells in the kidney, skeletal muscle, liver, lungs, heart, and bone marrow, which stimulates production of T cells, esp. cytotoxic T cells and natural killer cells. It can bind with interleukin-2 receptors and mimic IL-2's effects. See: interleukin-2


Abbreviation: IL-16
A cytokine produced by T lymphocytes that stimulates movement of monocytes, CD4+ T cells, and eosinophils to the area. It was previously known as lymphocyte chemoattractant factor.


Abbreviation: IL-17
A cytokine produced by memory T lymphocytes that stimulates the proliferation of T cells and the differentiation of neutrophils.


Abbreviation: IL-18
A cytokine produced by macrophages that stimulates the production of gamma interferon and other chemical mediators that enhance cell-mediated immune responses. It is similar in structure to IL-1.


Abbreviation: IL-8
A cytokine produced by many cell types. It acts as a neutrophil chemoattractant.
See also: interleukin
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
In activated RASFs, ST2 negatively affected IL-33, IL-1[sz], TNF-a, IL-6, and IL-8. In the PBMC culture study, soluble ST2 showed no effects on these inflammatory cytokines which might be attributed to the fact that there was no IL-33 expression in human PBMCs.[17] Therefore, we thought that the negative effects of soluble ST2 on the above inflammatory cytokines might depend on IL-33 levels and these inflammatory cytokines might be downstream of IL-33.
In the present study, we also demonstrated the role of soluble ST2 on cytokines, including IL-33, IL-1[sz], TNF-a, IL-6, and IL-8. After soluble ST2 treatment, the expressions of both IL-1[sz] and IL-33 were downregulated in resting RASFs, but the expressions of TNF-a, IL-6, and IL-8 were not affected.
(b) Cytokine gene expression in IRIS groups before and after HAART; IL-1[beta], IL-6, IL-8, and TNF-[alpha] expression from low to high; TNF-[alpha] gene expression also increased in non-IRIS group after HAART; ** the gene expressions after HAART were higher than those before treatment.
IL-6 and IL-8 expressions were obviously lower in IRIS group; * before HAART, the gene expressions in IRIS group were lower than those in non-IRIS group.
The concentrations of serum IL-6 and urine IL-6, IL-8, and TNF in HFRS patients increased with the increasing severity of the disease, and differed significantly in each type.
However IL-15R protein expres-sion was induced while the cells were exposed to IL-15, IL-8, or a combination of IL-1 b and TNF- a.
To investigate the influence of storage conditions on the IL-8 concentration of the lysate samples, lysate obtained from individual EDTA blood samples was aliquoted into 1.5-mL polypropylene tubes (0.2-mL aliquots) and stored for different periods at room temperature, at 4[degrees]C, or frozen at -20 and -80[degrees]C.
Zachariae et al., "IL-8 as antibody therapeutic target in inflammatory diseases: reduction of clinical activity in palmoplantar pustulosis," The Journal of Immunology, vol.
Ascitic fluid IL-8 concentrations were greater in SBP patients than in the SA group (P <0.000001; Table 1).
Bland-Altman analyses revealed that agreement was moderate for IL-1[beta], IL-5, IL-6, IL-8, and MIP-1[beta] and low for IL-4, IL-7, IL-12p70, IL-13, G-CSF, IFN-[gamma], TNF-[alpha], and MCP-1.