IL-5


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Related to IL-5: IL-13, Il-10, Il-4

IL5

A gene on chromosome 5q31.1 that encodes interleukin-5, a cytokine which acts as a  growth and differentiation factor for B cells (inducing the terminal differentiation of late-developing B-cells to immunoglobulin secreting cell) and eosinophils, for the latter of which IL5 is a key regulator of eosinopoiesis, eosinophil maturation and activation.

interleukin

(in?ter-loo'kin),

IL

A type of cytokine that enables communication among leukocytes and other cells active in inflammation or the specific immune response. The result is a maximized response to a microorganism or other foreign antigen. See: cell-mediated immunity; cytokine; inflammation

interleukin-1

Abbreviation: IL-1
A cytokine released by almost all nucleated cells that activates the growth and function of neutrophils, lymphocytes, and macrophages; promotes the release of additional mediators that influence immune responses; enhances production of cerebrospinal fluid; and modulates certain adrenal, hepatic, bone, and vascular smooth muscle cell activity. Interleukin-1 and tumor necrosis factors, whose actions are almost identical to those of IL-1, are involved in fever production and other systemic effects of inflammation. See: tumor necrosis factor

interleukin-1-beta

Abbreviation: IL-1-ß
A protein released by activated macrophages that stimulates B cells and thymocytes to proliferate and mature and increases the secretion of interleukin 2. It is found in high levels in the blood of patients with septic shock and in the cerebrospinal fluid of patients with meningitis.
Synonym: catabolin

interleukin-2

Abbreviation: IL-2
A cytokine released primarily by activated CD4+ helper T lymphocytes. It is a major mediator of T cell proliferation, promotes production of other cytokines, enhances natural killer cell function, and is a cofactor for immunoglobulin secretion. Synonym: T-cell growth factor

interleukin-3

Abbreviation: IL-3
A cytokine produced by activated T cells that promotes proliferation of bone marrow stem cells.
Synonym: mast cell growth factor; multi-colony stimulating factor

interleukin-4

Abbreviation: IL-4
A cytokine released by activated T cells and mast cells that stimulates B and T lymphocyte production and activity, prevents macrophages from releasing monokines, and promotes mast cell, immunoglobulin E, and eosinophil activity.
Synonym: B cell growth factor; mast cell growth factor II; T-cell growth factor II

interleukin-5

Abbreviation: IL-5
A cytokine produced by T cells, eosinophils and mast cells that acts as the primary stimulant for eosinophil production. Synonym: eosinophil colony-stimulating factor; eosinophil differentiation factor See: basophil(e); eosinophil

interleukin-6

Abbreviation: IL-6
A lymphokine produced by many cell types, including mononuclear phagocytes, T cells, and endothelial cells. It mediates the acute phase response, enhances B cell production and differentiation to immunoglobulin-secreting plasma cells, and stimulates megakaryocyte production. Synonym: B cell stimulatory factor II; hepatocyte stimulatory factor See: acute phase reaction; lymphokine

interleukin-7

Abbreviation: IL-7
A cytokine produced by the thymus, spleen, and bone marrow stromal cells. It stimulates growth of B-cell precursors, development of thymocytes, and activity of cytotoxic T-cells.
Synonym: lymphopoietin 1; pre-B cell growth factor

interleukin-8

Abbreviation: IL-8
A cytokine produced by many cell types. It acts as a neutrophil chemoattractant.

interleukin-9

Abbreviation: IL-9
A cytokine produced by T cells. Among other functions, it promotes the proliferation and multiplication of mast cells.

interleukin-10

Abbreviation: IL-10
A cytokine derived from mononuclear phagocytes, T cells, and keratinocytes. It inhibits cytokine synthesis by macrophages, T cells, and natural killer cells, and enhances B cell growth and secretion of immunoglobulin.

interleukin-11

Abbreviation: IL-11
A cytokine produced by bone marrow stromal cells. It mediates acute phase protein synthesis, enhances B cell growth and differentiation to plasma cells, and promotes megakaryocyte production.
Synonym: plasmocytoma stimulating factor

interleukin-12

Abbreviation: IL-12
A cytokine produced by mononuclear phagocytes and B cells. It induces interferon gamma production from T cells and natural killer cells, and enhances T cell and natural killer cell cytotoxicity.
Synonym: natural killer cell stimulating factor

interleukin-13

Abbreviation: IL-13
A cytokine produced by T cells. It induces major histocompatibility class II expression on mononuclear phagocytes and B cells, B cell proliferation, and immunoglobulin production.

interleukin-14

Abbreviation: IL-14
A cytokine produced by T lymphocytes and follicular dendritic cells. It stimulates proliferation of activated B lymphocytes and inhibits immunoglobulin secretion from activated B lymphocytes.

interleukin-15

Abbreviation: IL-15
A cytokine released by epithelial cells in the kidney, skeletal muscle, liver, lungs, heart, and bone marrow, which stimulates production of T cells, esp. cytotoxic T cells and natural killer cells. It can bind with interleukin-2 receptors and mimic IL-2's effects. See: interleukin-2

interleukin-16

Abbreviation: IL-16
A cytokine produced by T lymphocytes that stimulates movement of monocytes, CD4+ T cells, and eosinophils to the area. It was previously known as lymphocyte chemoattractant factor.

interleukin-17

Abbreviation: IL-17
A cytokine produced by memory T lymphocytes that stimulates the proliferation of T cells and the differentiation of neutrophils.

interleukin-18

Abbreviation: IL-18
A cytokine produced by macrophages that stimulates the production of gamma interferon and other chemical mediators that enhance cell-mediated immune responses. It is similar in structure to IL-1.

interleukin-5

Abbreviation: IL-5
A cytokine produced by T cells, eosinophils and mast cells that acts as the primary stimulant for eosinophil production. Synonym: eosinophil colony-stimulating factor; eosinophil differentiation factor See: basophil(e); eosinophil
See also: interleukin
References in periodicals archive ?
Table-I: Serum levels of IL-4, IL-5 and IL-10 (ng/L, X +- s).
Table-III: Results of rank-sum test with completely randomly designed multiple sample comparison for serum IL-4, IL-5 and IL-10.
Serum levels of IL-4, IL-5 and IL-10: The serum levels of IL-4 in control, allergic rhinitis, asthma and complication groups were (5.23+-2.78), (82.17+-32.45), (69.42+-36.19) and (80.65+-33.01) ng/L, respectively.
Results of rank-sum test with completely randomly designed multiple sample comparison for serum IL-4, IL-5 and IL-10: The IL-4, IL-5 and IL-10 levels of allergic rhinitis, asthma and complication groups were significantly different from those of the control group (P<0.01) (Table-III).The IL-5 levels of allergic rhinitis and asthma groups were significantly different (P<0.01).
The potential roles of cytokines, IL-5 and IL-8, and plasma cortisol in the anti-inflammatory actions of phosphodiesterase inhibitors in sensitized guinea-pig airways.
Similarly, antagonizing IL-33's biological effects, using anti-ST2 blocking antibodies, was effective in ameliorating joint inflammation in a murine model of rheumatoid arthritis [46]; in fact, the administration of IL-33 to cultures of immune cells isolated from murine inflamed joints led to a dramatic increase in IL-5, IL-6, and IL-17 production [45, 46].
The anti-inflammatory effects of IL-33 appeared to be mediated by a decreased production of the prototypic Th1 cytokine, IFN[gamma], while the Th2 cytokines, IL-5 and IL-13, were found to be increased.
Bland-Altman analyses revealed that agreement was moderate for IL-1[beta], IL-5, IL-6, IL-8, and MIP-1[beta] and low for IL-4, IL-7, IL-12p70, IL-13, G-CSF, IFN-[gamma], TNF-[alpha], and MCP-1.
In plasma, ICCs indicated poor agreement between the baseline and after a thaw-freeze cycle for IL-4, IL-5, IL-6, IL-8, TNF-[alpha], IFN-[gamma], IL-12p70, IL-13, G-CSF, MCP-1, and MIP-1[beta].
In serum, ICCs suggested poor agreements between the baseline and after a thaw-freeze cycle for IL-1[beta], IL-4, IL-5, IL-6, IL-8, TNF-[alpha], IFN-[gamma], IL-12p70, IL-13, G-CSF, MCP-1, and substantial agreements for IL-17 and MIP-1[beta].
At baseline, the ICCs suggested poor agreement between serum and plasma sample levels for IL-1[beta], IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12p70, IL-13, IL-17, G-CSF, GM-CSF, TNF-[alpha], IFN-[gamma], MCP-1, and MIP-1[beta].